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Psychosis of Epilepsy: A 10-Year Iranian Clinical Survey

Objective: Psychoses of epilepsy usually have an acute onset, accompanied by brief symptom duration and a risk of recurrence. Managing these conditions can be challenging due to the potential for seizures associated with certain antipsychotic medications, as well as exacerbating psychosis resulting...

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Autores principales: Shafie, Mahan, Darijani, Jaber, Mirsepassi, Zahra, Razavi, Alireza, Mayeli, Mahsa, Arbabi, Mohammad, Aghamollaii, Vajiheh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Psychiatry & Psychology Research Center, Tehran University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593996/
https://www.ncbi.nlm.nih.gov/pubmed/37881424
http://dx.doi.org/10.18502/ijps.v18i4.13634
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author Shafie, Mahan
Darijani, Jaber
Mirsepassi, Zahra
Razavi, Alireza
Mayeli, Mahsa
Arbabi, Mohammad
Aghamollaii, Vajiheh
author_facet Shafie, Mahan
Darijani, Jaber
Mirsepassi, Zahra
Razavi, Alireza
Mayeli, Mahsa
Arbabi, Mohammad
Aghamollaii, Vajiheh
author_sort Shafie, Mahan
collection PubMed
description Objective: Psychoses of epilepsy usually have an acute onset, accompanied by brief symptom duration and a risk of recurrence. Managing these conditions can be challenging due to the potential for seizures associated with certain antipsychotic medications, as well as exacerbating psychosis resulting from some antiepileptic medications. Our objective in this study was to assess the occurrence of psychosis among patients with epilepsy, as well as identify the factors linked to the presence and severity of psychosis in this population. Method : In this study, we included a total of 514 subjects diagnosed with epilepsy referring to our neuropsychiatry clinic affiliated with Tehran University of Medical Sciences from April 2011 to December 2021, among whom 57 patients showed psychotic presentations. We compared baseline and clinical characteristics between patients with psychosis of epilepsy and non-psychosis patients who also had epilepsy. Results: Marital status was the sole demographic factor that displayed a statistically significant difference between the psychosis and non-psychosis groups (P = 0.019). There was no significant difference observed between the two groups regarding family history of epilepsy and age at the onset of the epilepsy. Patients with psychosis experienced significantly more frequent seizures and generalized type (P < 0.001). Participants were matched for demographics and other clinical factors between the refractory and controlled psychosis groups, except for the psychosis frequency (P = 0.007). The type of epilepsy was significantly associated with psychosis when adjusted for the covariates (P < 0.001). Conclusion: Patients with psychosis of epilepsy experienced more episodes of epilepsy than non-psychotics. We identified generalized epilepsy as an independent risk factor for the development of psychosis. Additional cohorts are warranted to explore the factors associated with epilepsy-related psychosis across diverse populations.
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spelling pubmed-105939962023-10-25 Psychosis of Epilepsy: A 10-Year Iranian Clinical Survey Shafie, Mahan Darijani, Jaber Mirsepassi, Zahra Razavi, Alireza Mayeli, Mahsa Arbabi, Mohammad Aghamollaii, Vajiheh Iran J Psychiatry Original Article Objective: Psychoses of epilepsy usually have an acute onset, accompanied by brief symptom duration and a risk of recurrence. Managing these conditions can be challenging due to the potential for seizures associated with certain antipsychotic medications, as well as exacerbating psychosis resulting from some antiepileptic medications. Our objective in this study was to assess the occurrence of psychosis among patients with epilepsy, as well as identify the factors linked to the presence and severity of psychosis in this population. Method : In this study, we included a total of 514 subjects diagnosed with epilepsy referring to our neuropsychiatry clinic affiliated with Tehran University of Medical Sciences from April 2011 to December 2021, among whom 57 patients showed psychotic presentations. We compared baseline and clinical characteristics between patients with psychosis of epilepsy and non-psychosis patients who also had epilepsy. Results: Marital status was the sole demographic factor that displayed a statistically significant difference between the psychosis and non-psychosis groups (P = 0.019). There was no significant difference observed between the two groups regarding family history of epilepsy and age at the onset of the epilepsy. Patients with psychosis experienced significantly more frequent seizures and generalized type (P < 0.001). Participants were matched for demographics and other clinical factors between the refractory and controlled psychosis groups, except for the psychosis frequency (P = 0.007). The type of epilepsy was significantly associated with psychosis when adjusted for the covariates (P < 0.001). Conclusion: Patients with psychosis of epilepsy experienced more episodes of epilepsy than non-psychotics. We identified generalized epilepsy as an independent risk factor for the development of psychosis. Additional cohorts are warranted to explore the factors associated with epilepsy-related psychosis across diverse populations. Psychiatry & Psychology Research Center, Tehran University of Medical Sciences 2023-10 /pmc/articles/PMC10593996/ /pubmed/37881424 http://dx.doi.org/10.18502/ijps.v18i4.13634 Text en Copyright © 2023 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Original Article
Shafie, Mahan
Darijani, Jaber
Mirsepassi, Zahra
Razavi, Alireza
Mayeli, Mahsa
Arbabi, Mohammad
Aghamollaii, Vajiheh
Psychosis of Epilepsy: A 10-Year Iranian Clinical Survey
title Psychosis of Epilepsy: A 10-Year Iranian Clinical Survey
title_full Psychosis of Epilepsy: A 10-Year Iranian Clinical Survey
title_fullStr Psychosis of Epilepsy: A 10-Year Iranian Clinical Survey
title_full_unstemmed Psychosis of Epilepsy: A 10-Year Iranian Clinical Survey
title_short Psychosis of Epilepsy: A 10-Year Iranian Clinical Survey
title_sort psychosis of epilepsy: a 10-year iranian clinical survey
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593996/
https://www.ncbi.nlm.nih.gov/pubmed/37881424
http://dx.doi.org/10.18502/ijps.v18i4.13634
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