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Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder?
Objective: Tic disorder (TD) is one of the neurodevelopmental disorders and its etiology has not been fully elucidated. Complete blood count (CBC) values have been used as indicators of a systemic inflammatory response. In our study, we aimed to assess hemogram parameters in drug-naive, comorbidity-...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594065/ https://www.ncbi.nlm.nih.gov/pubmed/37881325 http://dx.doi.org/10.7759/cureus.47280 |
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author | Kara, Mahmut Zabit Kul, Müslüm |
author_facet | Kara, Mahmut Zabit Kul, Müslüm |
author_sort | Kara, Mahmut Zabit |
collection | PubMed |
description | Objective: Tic disorder (TD) is one of the neurodevelopmental disorders and its etiology has not been fully elucidated. Complete blood count (CBC) values have been used as indicators of a systemic inflammatory response. In our study, we aimed to assess hemogram parameters in drug-naive, comorbidity-free children with TD compared with controls. Methods: This retrospective study included 62 drug-naive children with TD who had undergone CBC within one month prior to the study. A control group of 48 healthy children, matched for age and gender, without any organic or psychiatric disorders, was included. Statistical analysis was performed by using IBM SPSS Statistics for Windows, Version 22.0 (Released 2013; IBM Corp., Armonk, New York, United States). Results: Hematocrit (p = 0.044), mean corpuscular volume (p = 0.002), platelet count (p = 0.011), and plateletcrit (p = 0.031) values were significantly higher in the TD group, whereas mean corpuscular hemoglobin concentration (p = 0.00) was significantly lower in the TD group. Additionally, a significant negative correlation was observed between the duration of illness and platelet (p = 0.05, r=-0.282), plateletcrit (p = 0.038, r = -0.295), and neutrophil count (p = 0.006, r = -0.391), while a positive correlation was found between the duration of illness and eosinophil count (p = 0.018, r = 0.336). Conclusion: The results revealed several significant differences in hemogram parameters between TD patients and the control group. These may suggest the role of inflammation and/or other underlying mechanisms in TD and may inspire new studies. Future studies with larger and more homogeneous samples, including comprehensive inflammatory markers, may contribute to a deeper understanding of the relationship between inflammation and TD. |
format | Online Article Text |
id | pubmed-10594065 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-105940652023-10-25 Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder? Kara, Mahmut Zabit Kul, Müslüm Cureus Pediatrics Objective: Tic disorder (TD) is one of the neurodevelopmental disorders and its etiology has not been fully elucidated. Complete blood count (CBC) values have been used as indicators of a systemic inflammatory response. In our study, we aimed to assess hemogram parameters in drug-naive, comorbidity-free children with TD compared with controls. Methods: This retrospective study included 62 drug-naive children with TD who had undergone CBC within one month prior to the study. A control group of 48 healthy children, matched for age and gender, without any organic or psychiatric disorders, was included. Statistical analysis was performed by using IBM SPSS Statistics for Windows, Version 22.0 (Released 2013; IBM Corp., Armonk, New York, United States). Results: Hematocrit (p = 0.044), mean corpuscular volume (p = 0.002), platelet count (p = 0.011), and plateletcrit (p = 0.031) values were significantly higher in the TD group, whereas mean corpuscular hemoglobin concentration (p = 0.00) was significantly lower in the TD group. Additionally, a significant negative correlation was observed between the duration of illness and platelet (p = 0.05, r=-0.282), plateletcrit (p = 0.038, r = -0.295), and neutrophil count (p = 0.006, r = -0.391), while a positive correlation was found between the duration of illness and eosinophil count (p = 0.018, r = 0.336). Conclusion: The results revealed several significant differences in hemogram parameters between TD patients and the control group. These may suggest the role of inflammation and/or other underlying mechanisms in TD and may inspire new studies. Future studies with larger and more homogeneous samples, including comprehensive inflammatory markers, may contribute to a deeper understanding of the relationship between inflammation and TD. Cureus 2023-10-18 /pmc/articles/PMC10594065/ /pubmed/37881325 http://dx.doi.org/10.7759/cureus.47280 Text en Copyright © 2023, Kara et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Pediatrics Kara, Mahmut Zabit Kul, Müslüm Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder? |
title | Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder? |
title_full | Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder? |
title_fullStr | Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder? |
title_full_unstemmed | Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder? |
title_short | Can Red Blood Cell and Platelet Parameters Be Associated With Inflammation in Children With Tic Disorder? |
title_sort | can red blood cell and platelet parameters be associated with inflammation in children with tic disorder? |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594065/ https://www.ncbi.nlm.nih.gov/pubmed/37881325 http://dx.doi.org/10.7759/cureus.47280 |
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