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Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay

IMPORTANCE: Although the effects of lead (Pb) exposure on neurocognition in children have been confirmed, the individual associations of prenatal Pb exposure and its interaction with genetic factors on cognitive developmental delay (CDD) in children remain unclear. OBJECTIVE: To investigate the asso...

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Autores principales: Jia, Zhenxian, Zhang, Hongling, Yu, Ling, Qiu, Feng, Lv, Yiqing, Guan, Jing, Gang, Huiqing, Zuo, Jingwen, Zheng, Tongzhang, Liu, Hongxiu, Xia, Wei, Xu, Shunqing, Li, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Medical Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594149/
https://www.ncbi.nlm.nih.gov/pubmed/37870833
http://dx.doi.org/10.1001/jamanetworkopen.2023.39108
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author Jia, Zhenxian
Zhang, Hongling
Yu, Ling
Qiu, Feng
Lv, Yiqing
Guan, Jing
Gang, Huiqing
Zuo, Jingwen
Zheng, Tongzhang
Liu, Hongxiu
Xia, Wei
Xu, Shunqing
Li, Yuanyuan
author_facet Jia, Zhenxian
Zhang, Hongling
Yu, Ling
Qiu, Feng
Lv, Yiqing
Guan, Jing
Gang, Huiqing
Zuo, Jingwen
Zheng, Tongzhang
Liu, Hongxiu
Xia, Wei
Xu, Shunqing
Li, Yuanyuan
author_sort Jia, Zhenxian
collection PubMed
description IMPORTANCE: Although the effects of lead (Pb) exposure on neurocognition in children have been confirmed, the individual associations of prenatal Pb exposure and its interaction with genetic factors on cognitive developmental delay (CDD) in children remain unclear. OBJECTIVE: To investigate the association of prenatal Pb exposure and its interaction with genetic factors with CDD risk. DESIGN, SETTING, AND PARTICIPANTS: Women in Wuhan, China, who had an expected delivery date between March 2014 and December 2017, were recruited for this prospective cohort study. Children were assessed for cognitive development at approximately 2 years of age (March 2016 to December 2019). Maternal venous blood, cord blood, and venous blood from children were collected in a longitudinal follow-up. Data analysis was performed from March 2022 to February 2023. EXPOSURE: Prenatal Pb exposure, and genetic risk for cognitive ability evaluated by polygenic risk score constructed with 58 genetic variations. MAIN OUTCOMES AND MEASURES: Cognitive developmental delay of children aged approximately 2 years was assessed using the Chinese revision of the Bayley Scale of Infant Development. A series of multivariable logistic regressions was estimated to determine associations between prenatal Pb exposure and CDD among children with various genetic backgrounds, adjusting for confounding variables. RESULTS: This analysis included 2361 eligible mother-child pairs (1240 boys [52.5%] and 1121 girls [47.5%]; mean [SD] ages of mothers and children, 28.9 [3.6] years and 24.8 [1.0] months, respectively), with 292 children (12.4%) having CDD. Higher maternal Pb levels were significantly associated with increased risk of CDD (highest vs lowest tertile: odds ratio, 1.55; 95% CI, 1.13-2.13), adjusting for demographic confounders. The association of CDD with maternal Pb levels was more evident among children with higher genetic risk (highest vs lowest tertile: odds ratio, 2.59; 95% CI, 1.48-4.55), adjusting for demographic confounders. CONCLUSIONS AND RELEVANCE: In this cohort study, prenatal Pb exposure was associated with an increased risk of CDD in children, especially in those with a high genetic risk. These findings suggest that prenatal Pb exposure and genetic background may jointly contribute to an increased risk of CDD for children and indicate the possibility for an integrated strategy to assess CDD risk and improve children’s cognitive ability.
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spelling pubmed-105941492023-10-25 Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay Jia, Zhenxian Zhang, Hongling Yu, Ling Qiu, Feng Lv, Yiqing Guan, Jing Gang, Huiqing Zuo, Jingwen Zheng, Tongzhang Liu, Hongxiu Xia, Wei Xu, Shunqing Li, Yuanyuan JAMA Netw Open Original Investigation IMPORTANCE: Although the effects of lead (Pb) exposure on neurocognition in children have been confirmed, the individual associations of prenatal Pb exposure and its interaction with genetic factors on cognitive developmental delay (CDD) in children remain unclear. OBJECTIVE: To investigate the association of prenatal Pb exposure and its interaction with genetic factors with CDD risk. DESIGN, SETTING, AND PARTICIPANTS: Women in Wuhan, China, who had an expected delivery date between March 2014 and December 2017, were recruited for this prospective cohort study. Children were assessed for cognitive development at approximately 2 years of age (March 2016 to December 2019). Maternal venous blood, cord blood, and venous blood from children were collected in a longitudinal follow-up. Data analysis was performed from March 2022 to February 2023. EXPOSURE: Prenatal Pb exposure, and genetic risk for cognitive ability evaluated by polygenic risk score constructed with 58 genetic variations. MAIN OUTCOMES AND MEASURES: Cognitive developmental delay of children aged approximately 2 years was assessed using the Chinese revision of the Bayley Scale of Infant Development. A series of multivariable logistic regressions was estimated to determine associations between prenatal Pb exposure and CDD among children with various genetic backgrounds, adjusting for confounding variables. RESULTS: This analysis included 2361 eligible mother-child pairs (1240 boys [52.5%] and 1121 girls [47.5%]; mean [SD] ages of mothers and children, 28.9 [3.6] years and 24.8 [1.0] months, respectively), with 292 children (12.4%) having CDD. Higher maternal Pb levels were significantly associated with increased risk of CDD (highest vs lowest tertile: odds ratio, 1.55; 95% CI, 1.13-2.13), adjusting for demographic confounders. The association of CDD with maternal Pb levels was more evident among children with higher genetic risk (highest vs lowest tertile: odds ratio, 2.59; 95% CI, 1.48-4.55), adjusting for demographic confounders. CONCLUSIONS AND RELEVANCE: In this cohort study, prenatal Pb exposure was associated with an increased risk of CDD in children, especially in those with a high genetic risk. These findings suggest that prenatal Pb exposure and genetic background may jointly contribute to an increased risk of CDD for children and indicate the possibility for an integrated strategy to assess CDD risk and improve children’s cognitive ability. American Medical Association 2023-10-23 /pmc/articles/PMC10594149/ /pubmed/37870833 http://dx.doi.org/10.1001/jamanetworkopen.2023.39108 Text en Copyright 2023 Jia Z et al. JAMA Network Open. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the CC-BY License.
spellingShingle Original Investigation
Jia, Zhenxian
Zhang, Hongling
Yu, Ling
Qiu, Feng
Lv, Yiqing
Guan, Jing
Gang, Huiqing
Zuo, Jingwen
Zheng, Tongzhang
Liu, Hongxiu
Xia, Wei
Xu, Shunqing
Li, Yuanyuan
Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay
title Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay
title_full Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay
title_fullStr Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay
title_full_unstemmed Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay
title_short Prenatal Lead Exposure, Genetic Factors, and Cognitive Developmental Delay
title_sort prenatal lead exposure, genetic factors, and cognitive developmental delay
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594149/
https://www.ncbi.nlm.nih.gov/pubmed/37870833
http://dx.doi.org/10.1001/jamanetworkopen.2023.39108
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