Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells

In developing B lymphocytes, a successful V(D)J heavy chain (HC) immunoglobulin (Ig) rearrangement establishes HC allelic exclusion and signals pro-B cells to advance in development to the pre-B stage. A subsequent functional light chain (LC) rearrangement then results in the surface expression of I...

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Detalles Bibliográficos
Autores principales: Tze, Lina E, Schram, Brian R, Lam, Kong-Peng, Hogquist, Kristin A, Hippen, Keli L, Liu, Jiabin, Shinton, Susan A, Otipoby, Kevin L, Rodine, Peter R, Vegoe, Amanda L, Kraus, Manfred, Hardy, Richard R, Schlissel, Mark S, Rajewsky, Klaus, Behrens, Timothy W
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2005
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1059451/
https://www.ncbi.nlm.nih.gov/pubmed/15752064
http://dx.doi.org/10.1371/journal.pbio.0030082

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