Cargando…

Targeting Neutrophil Extracellular Traps for Stroke Prognosis: A Promising Path

Stroke has become the first cause of functional disability and one of the leading causes of mortality worldwide. Therefore, it is of crucial importance to develop accurate biomarkers to assess stroke risk and prognosis. Emerging evidence suggests that neutrophil extracellular trap (NET) levels may s...

Descripción completa

Detalles Bibliográficos
Autores principales: Liaptsi, Eirini, Merkouris, Ermis, Polatidou, Efthymia, Tsiptsios, Dimitrios, Gkantzios, Aimilios, Kokkotis, Christos, Petridis, Foivos, Christidi, Foteini, Karatzetzou, Stella, Karaoglanis, Christos, Tsagkalidi, Anna-Maria, Chouliaras, Nikolaos, Tsamakis, Konstantinos, Protopapa, Maria, Pantazis-Pergaminelis, Dimitrios, Skendros, Panagiotis, Aggelousis, Nikolaos, Vadikolias, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594510/
https://www.ncbi.nlm.nih.gov/pubmed/37873833
http://dx.doi.org/10.3390/neurolint15040076
_version_ 1785124667069038592
author Liaptsi, Eirini
Merkouris, Ermis
Polatidou, Efthymia
Tsiptsios, Dimitrios
Gkantzios, Aimilios
Kokkotis, Christos
Petridis, Foivos
Christidi, Foteini
Karatzetzou, Stella
Karaoglanis, Christos
Tsagkalidi, Anna-Maria
Chouliaras, Nikolaos
Tsamakis, Konstantinos
Protopapa, Maria
Pantazis-Pergaminelis, Dimitrios
Skendros, Panagiotis
Aggelousis, Nikolaos
Vadikolias, Konstantinos
author_facet Liaptsi, Eirini
Merkouris, Ermis
Polatidou, Efthymia
Tsiptsios, Dimitrios
Gkantzios, Aimilios
Kokkotis, Christos
Petridis, Foivos
Christidi, Foteini
Karatzetzou, Stella
Karaoglanis, Christos
Tsagkalidi, Anna-Maria
Chouliaras, Nikolaos
Tsamakis, Konstantinos
Protopapa, Maria
Pantazis-Pergaminelis, Dimitrios
Skendros, Panagiotis
Aggelousis, Nikolaos
Vadikolias, Konstantinos
author_sort Liaptsi, Eirini
collection PubMed
description Stroke has become the first cause of functional disability and one of the leading causes of mortality worldwide. Therefore, it is of crucial importance to develop accurate biomarkers to assess stroke risk and prognosis. Emerging evidence suggests that neutrophil extracellular trap (NET) levels may serve as a valuable biomarker to predict stroke occurrence and functional outcome. NETs are known to create a procoagulant state by serving as a scaffold for tissue factor (TF) and platelets inducing thrombosis by activating coagulation pathways and endothelium. A literature search was conducted in two databases (MEDLINE and Scopus) to trace all relevant studies published between 1 January 2016 and 31 December 2022, addressing the potential utility of NETs as a stroke biomarker. Only full-text articles in English were included. The current review includes thirty-three papers. Elevated NET levels in plasma and thrombi seem to be associated with increased mortality and worse functional outcomes in stroke, with all acute ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage included. Additionally, higher NET levels seem to correlate with worse outcomes after recanalization therapies and are more frequently found in strokes of cardioembolic or cryptogenic origin. Additionally, total neutrophil count in plasma seems also to correlate with stroke severity. Overall, NETs may be a promising predictive tool to assess stroke severity, functional outcome, and response to recanalization therapies.
format Online
Article
Text
id pubmed-10594510
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-105945102023-10-25 Targeting Neutrophil Extracellular Traps for Stroke Prognosis: A Promising Path Liaptsi, Eirini Merkouris, Ermis Polatidou, Efthymia Tsiptsios, Dimitrios Gkantzios, Aimilios Kokkotis, Christos Petridis, Foivos Christidi, Foteini Karatzetzou, Stella Karaoglanis, Christos Tsagkalidi, Anna-Maria Chouliaras, Nikolaos Tsamakis, Konstantinos Protopapa, Maria Pantazis-Pergaminelis, Dimitrios Skendros, Panagiotis Aggelousis, Nikolaos Vadikolias, Konstantinos Neurol Int Review Stroke has become the first cause of functional disability and one of the leading causes of mortality worldwide. Therefore, it is of crucial importance to develop accurate biomarkers to assess stroke risk and prognosis. Emerging evidence suggests that neutrophil extracellular trap (NET) levels may serve as a valuable biomarker to predict stroke occurrence and functional outcome. NETs are known to create a procoagulant state by serving as a scaffold for tissue factor (TF) and platelets inducing thrombosis by activating coagulation pathways and endothelium. A literature search was conducted in two databases (MEDLINE and Scopus) to trace all relevant studies published between 1 January 2016 and 31 December 2022, addressing the potential utility of NETs as a stroke biomarker. Only full-text articles in English were included. The current review includes thirty-three papers. Elevated NET levels in plasma and thrombi seem to be associated with increased mortality and worse functional outcomes in stroke, with all acute ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage included. Additionally, higher NET levels seem to correlate with worse outcomes after recanalization therapies and are more frequently found in strokes of cardioembolic or cryptogenic origin. Additionally, total neutrophil count in plasma seems also to correlate with stroke severity. Overall, NETs may be a promising predictive tool to assess stroke severity, functional outcome, and response to recanalization therapies. MDPI 2023-09-28 /pmc/articles/PMC10594510/ /pubmed/37873833 http://dx.doi.org/10.3390/neurolint15040076 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Liaptsi, Eirini
Merkouris, Ermis
Polatidou, Efthymia
Tsiptsios, Dimitrios
Gkantzios, Aimilios
Kokkotis, Christos
Petridis, Foivos
Christidi, Foteini
Karatzetzou, Stella
Karaoglanis, Christos
Tsagkalidi, Anna-Maria
Chouliaras, Nikolaos
Tsamakis, Konstantinos
Protopapa, Maria
Pantazis-Pergaminelis, Dimitrios
Skendros, Panagiotis
Aggelousis, Nikolaos
Vadikolias, Konstantinos
Targeting Neutrophil Extracellular Traps for Stroke Prognosis: A Promising Path
title Targeting Neutrophil Extracellular Traps for Stroke Prognosis: A Promising Path
title_full Targeting Neutrophil Extracellular Traps for Stroke Prognosis: A Promising Path
title_fullStr Targeting Neutrophil Extracellular Traps for Stroke Prognosis: A Promising Path
title_full_unstemmed Targeting Neutrophil Extracellular Traps for Stroke Prognosis: A Promising Path
title_short Targeting Neutrophil Extracellular Traps for Stroke Prognosis: A Promising Path
title_sort targeting neutrophil extracellular traps for stroke prognosis: a promising path
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594510/
https://www.ncbi.nlm.nih.gov/pubmed/37873833
http://dx.doi.org/10.3390/neurolint15040076
work_keys_str_mv AT liaptsieirini targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT merkourisermis targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT polatidouefthymia targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT tsiptsiosdimitrios targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT gkantziosaimilios targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT kokkotischristos targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT petridisfoivos targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT christidifoteini targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT karatzetzoustella targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT karaoglanischristos targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT tsagkalidiannamaria targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT chouliarasnikolaos targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT tsamakiskonstantinos targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT protopapamaria targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT pantazispergaminelisdimitrios targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT skendrospanagiotis targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT aggelousisnikolaos targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath
AT vadikoliaskonstantinos targetingneutrophilextracellulartrapsforstrokeprognosisapromisingpath