Cargando…
The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC pathogenesis. Some of these pathways are part o...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594534/ https://www.ncbi.nlm.nih.gov/pubmed/37873809 http://dx.doi.org/10.3390/epigenomes7040024 |
_version_ | 1785124672627539968 |
---|---|
author | Androutsopoulos, Georgios Styliara, Ioanna Zarogianni, Evgenia Lazurko, Nadia Valasoulis, George Michail, Georgios Adonakis, Georgios |
author_facet | Androutsopoulos, Georgios Styliara, Ioanna Zarogianni, Evgenia Lazurko, Nadia Valasoulis, George Michail, Georgios Adonakis, Georgios |
author_sort | Androutsopoulos, Georgios |
collection | PubMed |
description | Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC pathogenesis. Some of these pathways are part of the EGF system signaling network, which becomes hyperactivated by various mechanisms and participates in cancer pathogenesis. In EC, the expression of ErbB receptors is significantly different, compared with the premenopausal and postmenopausal endometrium, mainly because of the increased transcriptional activity of ErbB encoding genes in EC cells. Moreover, there are some differences in ErbB-2 receptor profile among EC subgroups that could be explained by the alterations in pathophysiology and clinical behavior of various EC histologic subtypes. The fact that ErbB-2 receptor expression is more common in aggressive EC histologic subtypes (papillary serous and clear cell) could indicate a future role of ErbB-targeted therapies in well-defined EC subgroups with overexpression of ErbB receptors. |
format | Online Article Text |
id | pubmed-10594534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-105945342023-10-25 The ErbB Signaling Network and Its Potential Role in Endometrial Cancer Androutsopoulos, Georgios Styliara, Ioanna Zarogianni, Evgenia Lazurko, Nadia Valasoulis, George Michail, Georgios Adonakis, Georgios Epigenomes Review Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC pathogenesis. Some of these pathways are part of the EGF system signaling network, which becomes hyperactivated by various mechanisms and participates in cancer pathogenesis. In EC, the expression of ErbB receptors is significantly different, compared with the premenopausal and postmenopausal endometrium, mainly because of the increased transcriptional activity of ErbB encoding genes in EC cells. Moreover, there are some differences in ErbB-2 receptor profile among EC subgroups that could be explained by the alterations in pathophysiology and clinical behavior of various EC histologic subtypes. The fact that ErbB-2 receptor expression is more common in aggressive EC histologic subtypes (papillary serous and clear cell) could indicate a future role of ErbB-targeted therapies in well-defined EC subgroups with overexpression of ErbB receptors. MDPI 2023-10-01 /pmc/articles/PMC10594534/ /pubmed/37873809 http://dx.doi.org/10.3390/epigenomes7040024 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Androutsopoulos, Georgios Styliara, Ioanna Zarogianni, Evgenia Lazurko, Nadia Valasoulis, George Michail, Georgios Adonakis, Georgios The ErbB Signaling Network and Its Potential Role in Endometrial Cancer |
title | The ErbB Signaling Network and Its Potential Role in Endometrial Cancer |
title_full | The ErbB Signaling Network and Its Potential Role in Endometrial Cancer |
title_fullStr | The ErbB Signaling Network and Its Potential Role in Endometrial Cancer |
title_full_unstemmed | The ErbB Signaling Network and Its Potential Role in Endometrial Cancer |
title_short | The ErbB Signaling Network and Its Potential Role in Endometrial Cancer |
title_sort | erbb signaling network and its potential role in endometrial cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594534/ https://www.ncbi.nlm.nih.gov/pubmed/37873809 http://dx.doi.org/10.3390/epigenomes7040024 |
work_keys_str_mv | AT androutsopoulosgeorgios theerbbsignalingnetworkanditspotentialroleinendometrialcancer AT styliaraioanna theerbbsignalingnetworkanditspotentialroleinendometrialcancer AT zarogiannievgenia theerbbsignalingnetworkanditspotentialroleinendometrialcancer AT lazurkonadia theerbbsignalingnetworkanditspotentialroleinendometrialcancer AT valasoulisgeorge theerbbsignalingnetworkanditspotentialroleinendometrialcancer AT michailgeorgios theerbbsignalingnetworkanditspotentialroleinendometrialcancer AT adonakisgeorgios theerbbsignalingnetworkanditspotentialroleinendometrialcancer AT androutsopoulosgeorgios erbbsignalingnetworkanditspotentialroleinendometrialcancer AT styliaraioanna erbbsignalingnetworkanditspotentialroleinendometrialcancer AT zarogiannievgenia erbbsignalingnetworkanditspotentialroleinendometrialcancer AT lazurkonadia erbbsignalingnetworkanditspotentialroleinendometrialcancer AT valasoulisgeorge erbbsignalingnetworkanditspotentialroleinendometrialcancer AT michailgeorgios erbbsignalingnetworkanditspotentialroleinendometrialcancer AT adonakisgeorgios erbbsignalingnetworkanditspotentialroleinendometrialcancer |