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The ErbB Signaling Network and Its Potential Role in Endometrial Cancer

Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC pathogenesis. Some of these pathways are part o...

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Autores principales: Androutsopoulos, Georgios, Styliara, Ioanna, Zarogianni, Evgenia, Lazurko, Nadia, Valasoulis, George, Michail, Georgios, Adonakis, Georgios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594534/
https://www.ncbi.nlm.nih.gov/pubmed/37873809
http://dx.doi.org/10.3390/epigenomes7040024
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author Androutsopoulos, Georgios
Styliara, Ioanna
Zarogianni, Evgenia
Lazurko, Nadia
Valasoulis, George
Michail, Georgios
Adonakis, Georgios
author_facet Androutsopoulos, Georgios
Styliara, Ioanna
Zarogianni, Evgenia
Lazurko, Nadia
Valasoulis, George
Michail, Georgios
Adonakis, Georgios
author_sort Androutsopoulos, Georgios
collection PubMed
description Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC pathogenesis. Some of these pathways are part of the EGF system signaling network, which becomes hyperactivated by various mechanisms and participates in cancer pathogenesis. In EC, the expression of ErbB receptors is significantly different, compared with the premenopausal and postmenopausal endometrium, mainly because of the increased transcriptional activity of ErbB encoding genes in EC cells. Moreover, there are some differences in ErbB-2 receptor profile among EC subgroups that could be explained by the alterations in pathophysiology and clinical behavior of various EC histologic subtypes. The fact that ErbB-2 receptor expression is more common in aggressive EC histologic subtypes (papillary serous and clear cell) could indicate a future role of ErbB-targeted therapies in well-defined EC subgroups with overexpression of ErbB receptors.
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spelling pubmed-105945342023-10-25 The ErbB Signaling Network and Its Potential Role in Endometrial Cancer Androutsopoulos, Georgios Styliara, Ioanna Zarogianni, Evgenia Lazurko, Nadia Valasoulis, George Michail, Georgios Adonakis, Georgios Epigenomes Review Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC pathogenesis. Some of these pathways are part of the EGF system signaling network, which becomes hyperactivated by various mechanisms and participates in cancer pathogenesis. In EC, the expression of ErbB receptors is significantly different, compared with the premenopausal and postmenopausal endometrium, mainly because of the increased transcriptional activity of ErbB encoding genes in EC cells. Moreover, there are some differences in ErbB-2 receptor profile among EC subgroups that could be explained by the alterations in pathophysiology and clinical behavior of various EC histologic subtypes. The fact that ErbB-2 receptor expression is more common in aggressive EC histologic subtypes (papillary serous and clear cell) could indicate a future role of ErbB-targeted therapies in well-defined EC subgroups with overexpression of ErbB receptors. MDPI 2023-10-01 /pmc/articles/PMC10594534/ /pubmed/37873809 http://dx.doi.org/10.3390/epigenomes7040024 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Androutsopoulos, Georgios
Styliara, Ioanna
Zarogianni, Evgenia
Lazurko, Nadia
Valasoulis, George
Michail, Georgios
Adonakis, Georgios
The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
title The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
title_full The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
title_fullStr The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
title_full_unstemmed The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
title_short The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
title_sort erbb signaling network and its potential role in endometrial cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594534/
https://www.ncbi.nlm.nih.gov/pubmed/37873809
http://dx.doi.org/10.3390/epigenomes7040024
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