Current Approaches to Epigenetic Therapy

Epigenetic therapy is a promising tool for the treatment of a wide range of diseases. Several fundamental epigenetic approaches have been proposed. Firstly, the use of small molecules as epigenetic effectors, as the most developed pharmacological method, has contributed to the introduction of a numb...

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Detalles Bibliográficos
Autores principales: Griazeva, Ekaterina D., Fedoseeva, Daria M., Radion, Elizaveta I., Ershov, Pavel V., Meshkov, Ivan O., Semyanihina, Alexandra V., Makarova, Anna S., Makarov, Valentin V., Yudin, Vladimir S., Keskinov, Anton A., Kraevoy, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594535/
https://www.ncbi.nlm.nih.gov/pubmed/37873808
http://dx.doi.org/10.3390/epigenomes7040023
Descripción
Sumario:Epigenetic therapy is a promising tool for the treatment of a wide range of diseases. Several fundamental epigenetic approaches have been proposed. Firstly, the use of small molecules as epigenetic effectors, as the most developed pharmacological method, has contributed to the introduction of a number of drugs into clinical practice. Secondly, various innovative epigenetic approaches based on dCas9 and the use of small non-coding RNAs as therapeutic agents are also under extensive research. In this review, we present the current state of research in the field of epigenetic therapy, considering the prospects for its application and possible limitations.

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