Extranodal marginal zone lymphoma: A case report

Non-Hodgkin lymphomas (NHLs) encompass a diverse range of lymphoproliferative neoplasms. Approximately 85%-90% of NHLs originate from mature B lymphocytes, with the remaining arising from T lymphocytes or natural killer (NK) cells. Notably, NHLs exhibit a pronounced extranodal predilection, with nearly 25% presenting in such locations. In developed countries, the most prevalent NHL subtypes are diffuse large B-cell lymphoma (accounting for 30%) and follicular lymphoma (representing 20%). All other NHL subtypes each constitute less than 10% of cases, including the rarer marginal zone lymphoma (MZL). We present a case involving a 70-year-old woman who experienced a palpable mass in the right hypochondrium. She displayed no peripheral adenopathies or systemic symptoms. Her diagnosis was established as MZL, posing a diagnostic challenge due to imaging findings that mimicked various infectious, benign, and malignant conditions.