STPP-UP: An alternative method for drug target identification using protein thermal stability

Thermal proteome profiling (TPP) has significantly advanced the field of drug discovery by facilitating proteome-wide identification of drug targets and off-targets. However, TPP has not been widely applied for high-throughput drug screenings, since the method is labor intensive and requires a lot o...

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Detalles Bibliográficos
Autores principales: Zijlmans, Dick W., Hernández-Quiles, Miguel, Jansen, Pascal W.T.C., Becher, Isabelle, Stein, Frank, Savitski, Mikhail M., Vermeulen, Michiel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Methods and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594562/
https://www.ncbi.nlm.nih.gov/pubmed/37742922
http://dx.doi.org/10.1016/j.jbc.2023.105279

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