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Nonlinear dielectric response of dilute protein solutions

A theory for the nonlinear dielectric response of dilute protein solutions is presented. The field-dependent dielectric function of the protein solution changes linearly with the electric field squared in the lowest order. The slope of this dependence is expressed in terms of the protein dipole mome...

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Autor principal: Matyushov, Dmitry V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594618/
https://www.ncbi.nlm.nih.gov/pubmed/37881764
http://dx.doi.org/10.1039/d3ra06033k
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author Matyushov, Dmitry V.
author_facet Matyushov, Dmitry V.
author_sort Matyushov, Dmitry V.
collection PubMed
description A theory for the nonlinear dielectric response of dilute protein solutions is presented. The field-dependent dielectric function of the protein solution changes linearly with the electric field squared in the lowest order. The slope of this dependence is expressed in terms of the protein dipole moment M(0), its volume fraction in solution η(0), and the second osmotic virial coefficient. For practical conditions, the nonlinear dielectric response scales as η(0)(3)M(0)(8). This strong dependence on the protein dipole moment and concentration establishes a sharp contrast between the nonlinear response of solvated proteins relative to the surrounding polar solvent. Nonlinear dielectric response can serve as a sensitive tool for monitoring protein conformations and physiological activity.
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spelling pubmed-105946182023-10-25 Nonlinear dielectric response of dilute protein solutions Matyushov, Dmitry V. RSC Adv Chemistry A theory for the nonlinear dielectric response of dilute protein solutions is presented. The field-dependent dielectric function of the protein solution changes linearly with the electric field squared in the lowest order. The slope of this dependence is expressed in terms of the protein dipole moment M(0), its volume fraction in solution η(0), and the second osmotic virial coefficient. For practical conditions, the nonlinear dielectric response scales as η(0)(3)M(0)(8). This strong dependence on the protein dipole moment and concentration establishes a sharp contrast between the nonlinear response of solvated proteins relative to the surrounding polar solvent. Nonlinear dielectric response can serve as a sensitive tool for monitoring protein conformations and physiological activity. The Royal Society of Chemistry 2023-10-24 /pmc/articles/PMC10594618/ /pubmed/37881764 http://dx.doi.org/10.1039/d3ra06033k Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Matyushov, Dmitry V.
Nonlinear dielectric response of dilute protein solutions
title Nonlinear dielectric response of dilute protein solutions
title_full Nonlinear dielectric response of dilute protein solutions
title_fullStr Nonlinear dielectric response of dilute protein solutions
title_full_unstemmed Nonlinear dielectric response of dilute protein solutions
title_short Nonlinear dielectric response of dilute protein solutions
title_sort nonlinear dielectric response of dilute protein solutions
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594618/
https://www.ncbi.nlm.nih.gov/pubmed/37881764
http://dx.doi.org/10.1039/d3ra06033k
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