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COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses
AIMS: It has been suggested that people with mental disorders have an elevated risk to acquire severe acute respiratory syndrome coronavirus 2 and to be disproportionally affected by coronavirus disease 19 (COVID-19) once infected. We aimed to analyse the COVID-19 infection rate, course and outcome,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594644/ https://www.ncbi.nlm.nih.gov/pubmed/37859501 http://dx.doi.org/10.1017/S2045796023000719 |
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author | Molero, Patricio Reina, Gabriel Blom, Jan Dirk Martínez-González, Miguel Ángel Reinken, Aischa de Kloet, E. Ronald Molendijk, Marc L. |
author_facet | Molero, Patricio Reina, Gabriel Blom, Jan Dirk Martínez-González, Miguel Ángel Reinken, Aischa de Kloet, E. Ronald Molendijk, Marc L. |
author_sort | Molero, Patricio |
collection | PubMed |
description | AIMS: It has been suggested that people with mental disorders have an elevated risk to acquire severe acute respiratory syndrome coronavirus 2 and to be disproportionally affected by coronavirus disease 19 (COVID-19) once infected. We aimed to analyse the COVID-19 infection rate, course and outcome, including mortality and long COVID, in people with anxiety, depressive, neurodevelopmental, schizophrenia spectrum and substance use disorders relative to control subjects without these disorders. METHODS: This study constitutes a preregistered systematic review and random-effects frequentist and Bayesian meta-analyses. Major databases were searched up until 27 June 2023. RESULTS: Eighty-one original articles were included reporting 304 cross-sectional and prospective effect size estimates (median n per effect-size = 114837) regarding associations of interest. Infection risk was not significantly increased for any mental disorder that we investigated relative to samples of people without these disorders. The course of COVID-19, however, is relatively severe, and long COVID and COVID-19-related hospitalization are more likely in all patient samples that we investigated. The odds of dying from COVID-19 were high in people with most types of mental disorders, except for those with anxiety and neurodevelopmental disorders relative to non-patient samples (pooled ORs range, 1.26–2.57). Bayesian analyses confirmed the findings from the frequentist approach and complemented them with estimates of the strength of evidence. CONCLUSIONS: Once infected, people with pre-existing mental disorders are at an elevated risk for a severe COVID-19 course and outcome, including long COVID and mortality, relative to people without pre-existing mental disorders, despite an infection risk not significantly increased. |
format | Online Article Text |
id | pubmed-10594644 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105946442023-10-25 COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses Molero, Patricio Reina, Gabriel Blom, Jan Dirk Martínez-González, Miguel Ángel Reinken, Aischa de Kloet, E. Ronald Molendijk, Marc L. Epidemiol Psychiatr Sci Original Article AIMS: It has been suggested that people with mental disorders have an elevated risk to acquire severe acute respiratory syndrome coronavirus 2 and to be disproportionally affected by coronavirus disease 19 (COVID-19) once infected. We aimed to analyse the COVID-19 infection rate, course and outcome, including mortality and long COVID, in people with anxiety, depressive, neurodevelopmental, schizophrenia spectrum and substance use disorders relative to control subjects without these disorders. METHODS: This study constitutes a preregistered systematic review and random-effects frequentist and Bayesian meta-analyses. Major databases were searched up until 27 June 2023. RESULTS: Eighty-one original articles were included reporting 304 cross-sectional and prospective effect size estimates (median n per effect-size = 114837) regarding associations of interest. Infection risk was not significantly increased for any mental disorder that we investigated relative to samples of people without these disorders. The course of COVID-19, however, is relatively severe, and long COVID and COVID-19-related hospitalization are more likely in all patient samples that we investigated. The odds of dying from COVID-19 were high in people with most types of mental disorders, except for those with anxiety and neurodevelopmental disorders relative to non-patient samples (pooled ORs range, 1.26–2.57). Bayesian analyses confirmed the findings from the frequentist approach and complemented them with estimates of the strength of evidence. CONCLUSIONS: Once infected, people with pre-existing mental disorders are at an elevated risk for a severe COVID-19 course and outcome, including long COVID and mortality, relative to people without pre-existing mental disorders, despite an infection risk not significantly increased. Cambridge University Press 2023-10-20 /pmc/articles/PMC10594644/ /pubmed/37859501 http://dx.doi.org/10.1017/S2045796023000719 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited. |
spellingShingle | Original Article Molero, Patricio Reina, Gabriel Blom, Jan Dirk Martínez-González, Miguel Ángel Reinken, Aischa de Kloet, E. Ronald Molendijk, Marc L. COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses |
title | COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses |
title_full | COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses |
title_fullStr | COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses |
title_full_unstemmed | COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses |
title_short | COVID-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses |
title_sort | covid-19 risk, course and outcome in people with mental disorders: a systematic review and meta-analyses |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594644/ https://www.ncbi.nlm.nih.gov/pubmed/37859501 http://dx.doi.org/10.1017/S2045796023000719 |
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