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Psychological characteristics associated with the brain volume of patients with fibromyalgia

Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with psychiatric symptoms such as anxiety and depression. It has been reported that FM patients engage in pain catastrophizing. In this study, we investigated characteristics of the brain volume of female FM patients...

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Autores principales: Izuno, Satoshi, Yoshihara, Kazufumi, Hosoi, Masako, Eto, Sanami, Hirabayashi, Naoki, Todani, Tae, Gondo, Motoharu, Hayaki, Chie, Anno, Kozo, Hiwatashi, Akio, Sudo, Nobuyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594713/
https://www.ncbi.nlm.nih.gov/pubmed/37875931
http://dx.doi.org/10.1186/s13030-023-00293-2
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author Izuno, Satoshi
Yoshihara, Kazufumi
Hosoi, Masako
Eto, Sanami
Hirabayashi, Naoki
Todani, Tae
Gondo, Motoharu
Hayaki, Chie
Anno, Kozo
Hiwatashi, Akio
Sudo, Nobuyuki
author_facet Izuno, Satoshi
Yoshihara, Kazufumi
Hosoi, Masako
Eto, Sanami
Hirabayashi, Naoki
Todani, Tae
Gondo, Motoharu
Hayaki, Chie
Anno, Kozo
Hiwatashi, Akio
Sudo, Nobuyuki
author_sort Izuno, Satoshi
collection PubMed
description Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with psychiatric symptoms such as anxiety and depression. It has been reported that FM patients engage in pain catastrophizing. In this study, we investigated characteristics of the brain volume of female FM patients and the association between psychological indices and brain volume. Thirty-nine female FM patients and 25 female healthy controls (HCs) were recruited for the study, and five FM patients were excluded due to white matter lesions. The following analyses were performed: (1) T1-weighted MRI were acquired for 34 FM patients (age 41.6 ± 7.4) and 25 HCs (age 39.5 ± 7.4). SPM12 was used to compare their gray and white matter volumes. (2) Data from anxiety and depression questionnaires (State-Trait Anxiety Inventory and Hospital Anxiety and Depression Scale), the Pain Catastrophizing Scale (subscales rumination, helplessness, magnification), and MRI were acquired for 34 FM patients (age 41.6 ± 7.4). Correlation analysis was done of the psychological indices and brain volume. We found that (1) The white matter volume of the temporal pole was larger in the FM patient group than in the HC group. (2) Correlation analysis of the psychological indices and gray matter volume showed a negative correlation between trait anxiety and the amygdala. For the white matter volume, positive correlations were found between depression and the brainstem and between magnification and the postcentral gyrus. Changes in the brain volume of female FM patients may be related to anxiety, depression, and pain catastrophizing.
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spelling pubmed-105947132023-10-25 Psychological characteristics associated with the brain volume of patients with fibromyalgia Izuno, Satoshi Yoshihara, Kazufumi Hosoi, Masako Eto, Sanami Hirabayashi, Naoki Todani, Tae Gondo, Motoharu Hayaki, Chie Anno, Kozo Hiwatashi, Akio Sudo, Nobuyuki Biopsychosoc Med Research Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with psychiatric symptoms such as anxiety and depression. It has been reported that FM patients engage in pain catastrophizing. In this study, we investigated characteristics of the brain volume of female FM patients and the association between psychological indices and brain volume. Thirty-nine female FM patients and 25 female healthy controls (HCs) were recruited for the study, and five FM patients were excluded due to white matter lesions. The following analyses were performed: (1) T1-weighted MRI were acquired for 34 FM patients (age 41.6 ± 7.4) and 25 HCs (age 39.5 ± 7.4). SPM12 was used to compare their gray and white matter volumes. (2) Data from anxiety and depression questionnaires (State-Trait Anxiety Inventory and Hospital Anxiety and Depression Scale), the Pain Catastrophizing Scale (subscales rumination, helplessness, magnification), and MRI were acquired for 34 FM patients (age 41.6 ± 7.4). Correlation analysis was done of the psychological indices and brain volume. We found that (1) The white matter volume of the temporal pole was larger in the FM patient group than in the HC group. (2) Correlation analysis of the psychological indices and gray matter volume showed a negative correlation between trait anxiety and the amygdala. For the white matter volume, positive correlations were found between depression and the brainstem and between magnification and the postcentral gyrus. Changes in the brain volume of female FM patients may be related to anxiety, depression, and pain catastrophizing. BioMed Central 2023-10-24 /pmc/articles/PMC10594713/ /pubmed/37875931 http://dx.doi.org/10.1186/s13030-023-00293-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Izuno, Satoshi
Yoshihara, Kazufumi
Hosoi, Masako
Eto, Sanami
Hirabayashi, Naoki
Todani, Tae
Gondo, Motoharu
Hayaki, Chie
Anno, Kozo
Hiwatashi, Akio
Sudo, Nobuyuki
Psychological characteristics associated with the brain volume of patients with fibromyalgia
title Psychological characteristics associated with the brain volume of patients with fibromyalgia
title_full Psychological characteristics associated with the brain volume of patients with fibromyalgia
title_fullStr Psychological characteristics associated with the brain volume of patients with fibromyalgia
title_full_unstemmed Psychological characteristics associated with the brain volume of patients with fibromyalgia
title_short Psychological characteristics associated with the brain volume of patients with fibromyalgia
title_sort psychological characteristics associated with the brain volume of patients with fibromyalgia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594713/
https://www.ncbi.nlm.nih.gov/pubmed/37875931
http://dx.doi.org/10.1186/s13030-023-00293-2
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