Cargando…
Psychological characteristics associated with the brain volume of patients with fibromyalgia
Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with psychiatric symptoms such as anxiety and depression. It has been reported that FM patients engage in pain catastrophizing. In this study, we investigated characteristics of the brain volume of female FM patients...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594713/ https://www.ncbi.nlm.nih.gov/pubmed/37875931 http://dx.doi.org/10.1186/s13030-023-00293-2 |
_version_ | 1785124706574139392 |
---|---|
author | Izuno, Satoshi Yoshihara, Kazufumi Hosoi, Masako Eto, Sanami Hirabayashi, Naoki Todani, Tae Gondo, Motoharu Hayaki, Chie Anno, Kozo Hiwatashi, Akio Sudo, Nobuyuki |
author_facet | Izuno, Satoshi Yoshihara, Kazufumi Hosoi, Masako Eto, Sanami Hirabayashi, Naoki Todani, Tae Gondo, Motoharu Hayaki, Chie Anno, Kozo Hiwatashi, Akio Sudo, Nobuyuki |
author_sort | Izuno, Satoshi |
collection | PubMed |
description | Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with psychiatric symptoms such as anxiety and depression. It has been reported that FM patients engage in pain catastrophizing. In this study, we investigated characteristics of the brain volume of female FM patients and the association between psychological indices and brain volume. Thirty-nine female FM patients and 25 female healthy controls (HCs) were recruited for the study, and five FM patients were excluded due to white matter lesions. The following analyses were performed: (1) T1-weighted MRI were acquired for 34 FM patients (age 41.6 ± 7.4) and 25 HCs (age 39.5 ± 7.4). SPM12 was used to compare their gray and white matter volumes. (2) Data from anxiety and depression questionnaires (State-Trait Anxiety Inventory and Hospital Anxiety and Depression Scale), the Pain Catastrophizing Scale (subscales rumination, helplessness, magnification), and MRI were acquired for 34 FM patients (age 41.6 ± 7.4). Correlation analysis was done of the psychological indices and brain volume. We found that (1) The white matter volume of the temporal pole was larger in the FM patient group than in the HC group. (2) Correlation analysis of the psychological indices and gray matter volume showed a negative correlation between trait anxiety and the amygdala. For the white matter volume, positive correlations were found between depression and the brainstem and between magnification and the postcentral gyrus. Changes in the brain volume of female FM patients may be related to anxiety, depression, and pain catastrophizing. |
format | Online Article Text |
id | pubmed-10594713 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105947132023-10-25 Psychological characteristics associated with the brain volume of patients with fibromyalgia Izuno, Satoshi Yoshihara, Kazufumi Hosoi, Masako Eto, Sanami Hirabayashi, Naoki Todani, Tae Gondo, Motoharu Hayaki, Chie Anno, Kozo Hiwatashi, Akio Sudo, Nobuyuki Biopsychosoc Med Research Fibromyalgia (FM) is a disease characterized by chronic widespread pain concomitant with psychiatric symptoms such as anxiety and depression. It has been reported that FM patients engage in pain catastrophizing. In this study, we investigated characteristics of the brain volume of female FM patients and the association between psychological indices and brain volume. Thirty-nine female FM patients and 25 female healthy controls (HCs) were recruited for the study, and five FM patients were excluded due to white matter lesions. The following analyses were performed: (1) T1-weighted MRI were acquired for 34 FM patients (age 41.6 ± 7.4) and 25 HCs (age 39.5 ± 7.4). SPM12 was used to compare their gray and white matter volumes. (2) Data from anxiety and depression questionnaires (State-Trait Anxiety Inventory and Hospital Anxiety and Depression Scale), the Pain Catastrophizing Scale (subscales rumination, helplessness, magnification), and MRI were acquired for 34 FM patients (age 41.6 ± 7.4). Correlation analysis was done of the psychological indices and brain volume. We found that (1) The white matter volume of the temporal pole was larger in the FM patient group than in the HC group. (2) Correlation analysis of the psychological indices and gray matter volume showed a negative correlation between trait anxiety and the amygdala. For the white matter volume, positive correlations were found between depression and the brainstem and between magnification and the postcentral gyrus. Changes in the brain volume of female FM patients may be related to anxiety, depression, and pain catastrophizing. BioMed Central 2023-10-24 /pmc/articles/PMC10594713/ /pubmed/37875931 http://dx.doi.org/10.1186/s13030-023-00293-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Izuno, Satoshi Yoshihara, Kazufumi Hosoi, Masako Eto, Sanami Hirabayashi, Naoki Todani, Tae Gondo, Motoharu Hayaki, Chie Anno, Kozo Hiwatashi, Akio Sudo, Nobuyuki Psychological characteristics associated with the brain volume of patients with fibromyalgia |
title | Psychological characteristics associated with the brain volume of patients with fibromyalgia |
title_full | Psychological characteristics associated with the brain volume of patients with fibromyalgia |
title_fullStr | Psychological characteristics associated with the brain volume of patients with fibromyalgia |
title_full_unstemmed | Psychological characteristics associated with the brain volume of patients with fibromyalgia |
title_short | Psychological characteristics associated with the brain volume of patients with fibromyalgia |
title_sort | psychological characteristics associated with the brain volume of patients with fibromyalgia |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594713/ https://www.ncbi.nlm.nih.gov/pubmed/37875931 http://dx.doi.org/10.1186/s13030-023-00293-2 |
work_keys_str_mv | AT izunosatoshi psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia AT yoshiharakazufumi psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia AT hosoimasako psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia AT etosanami psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia AT hirabayashinaoki psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia AT todanitae psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia AT gondomotoharu psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia AT hayakichie psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia AT annokozo psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia AT hiwatashiakio psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia AT sudonobuyuki psychologicalcharacteristicsassociatedwiththebrainvolumeofpatientswithfibromyalgia |