Identification and characterization of a small molecule that activates thiosulfate sulfurtransferase and stimulates mitochondrial respiration

The enzyme Thiosulfate sulfurtransferase (TST, EC 2.8.1.1), is a positive genetic predictor of diabetes type 2 and obesity. As increased TST activity protects against the development of diabetic symptoms in mice, an activating compound for TST may provide therapeutic benefits in diabetes and obesity...

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Detalles Bibliográficos
Autores principales: Al‐Dahmani, Zeyana M., Hadian, Mojgan, Ruiz‐Moreno, Angel J., Maria, Sabogal‐Guaqueta Angelica, Batista, Fernando A., Zhang, Ran, Luo, Yang, Sadremomtaz, Afsaneh, van der Straat, Robin, Spoor, Mette, Dolga, Amalia M., Dekker, Frank J., S S, Alexander Dömling, van Goor, Harry, Groves, Matthew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594923/
https://www.ncbi.nlm.nih.gov/pubmed/37800277
http://dx.doi.org/10.1002/pro.4794

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