Spore-FP1 tuberculosis mucosal vaccine candidate is highly protective in guinea pigs but fails to improve on BCG-conferred protection in non-human primates

Tuberculosis remains a major health threat globally and a more effective vaccine than the current Bacillus Calmette Guerin (BCG) is required, either to replace or boost it. The Spore-FP1 mucosal vaccine candidate is based on the fusion protein of Ag85B-Acr-HBHA/heparin-binding domain, adsorbed on th...

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Detalles Bibliográficos
Autores principales: White, Andrew D., Tran, Andy C., Sibley, Laura, Sarfas, Charlotte, Morrison, Alexandra L., Lawrence, Steve, Dennis, Mike, Clark, Simon, Zadi, Sirine, Lanni, Faye, Rayner, Emma, Copland, Alastair, Hart, Peter, Diogo, Gil Reynolds, Paul, Matthew J., Kim, Miyoung, Gleeson, Fergus, Salguero, Francisco J., Singh, Mahavir, Stehr, Matthias, Cutting, Simon M., Basile, Juan I., Rottenberg, Martin E., Williams, Ann, Sharpe, Sally A., Reljic, Rajko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10594996/
https://www.ncbi.nlm.nih.gov/pubmed/37881438
http://dx.doi.org/10.3389/fimmu.2023.1246826

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