Prevalence of fatigue in the general population during the pandemic: cross-sectional study in Geneva

BACKGROUND: Fatigue is a frequent symptom, the determinants of which are numerous and poorly understood. Fatigue also predicts ischemic heart disease, cancer, physical decline, and mortality. While the COVID-19 pandemic constituted a major stressor, no previous studies have measured the prevalence of fatigue and its determinants since the beginning of the pandemic in a general population. This study aims (1) to assess the prevalence of fatigue among the general population of the canton of Geneva, Switzerland, two years into the pandemic and (2) to analyse its determinants. METHODS: A cross-sectional population-based study was conducted as part of the Specchio-COVID19 cohort study. Adult participants answered an online health survey between March and May 2022. The main outcome was self-reported fatigue measured by the Chalder Fatigue Questionnaire. Other variables included general and mental health status, quality of life, and sociodemographic data. Multivariable logistic regressions were used to evaluate the determinants of fatigue. RESULTS: 4040 participants took part in the survey (participation rate 59%, respondents and non-respondents were comparable). The overall prevalence of fatigue was 31%. Significant determinants of fatigue were depression (aOR 10.49 [6.29-17.50], p < 0.001), diagnosis of a chronic disease in the past year (aOR 1.37 [1.12-1.68], p = 0.002), and an acute health event in the past year (aOR 1.44 [1.08-1.93], p = 0.014). 18-45-year-old people with a chronic disease were more likely to report fatigue (aOR 1.70 [1.04-2.77], p = 0.033). Male gender (aOR 0.72 [0.57-0.92], p = 0.007) or retirement (aOR 0.60 [0.43 - 0.85], p = 0.003) were protective factors. Age, level of education, and income were not significantly associated with fatigue. CONCLUSIONS: Fatigue was still highly prevalent in the general population two years into the COVID19 pandemic, comparing to regional prepandemic data. The cohort Specchio will monitor the evolution of fatigue after the pandemic. KEY MESSAGES: • Fatigue was still highly prevalent two years into the COVID19 pandemic among the general population in Geneva, comparing to regional prepandemic data. • Longitudinal follow-up is crucial to assess how fatigue is evolving after the pandemic.