Cargando…

Multi-Frequency RF Combined with Intense Pulsed Light Improves Signs and Symptoms of Dry Eye Disease Due to Meibomian Gland Dysfunction

PURPOSE: To evaluate the efficacy of multi-frequency RF and IPL + MGX combination for treatment of Meibomian Gland Dysfunction (MGD). PATIENTS AND METHODS: Eligible subjects had signs and moderate-to-severe symptoms of DED (Dry Eye Disease) due to MGD. Subjects underwent 4 treatments at 2-week inter...

Descripción completa

Detalles Bibliográficos
Autores principales: Chelnis, James, Garcia, Chantel N, Hamza, Haya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10595163/
https://www.ncbi.nlm.nih.gov/pubmed/37881780
http://dx.doi.org/10.2147/OPTH.S426564
_version_ 1785124803561127936
author Chelnis, James
Garcia, Chantel N
Hamza, Haya
author_facet Chelnis, James
Garcia, Chantel N
Hamza, Haya
author_sort Chelnis, James
collection PubMed
description PURPOSE: To evaluate the efficacy of multi-frequency RF and IPL + MGX combination for treatment of Meibomian Gland Dysfunction (MGD). PATIENTS AND METHODS: Eligible subjects had signs and moderate-to-severe symptoms of DED (Dry Eye Disease) due to MGD. Subjects underwent 4 treatments at 2-week intervals. Each treatment consisted of intense pulsed light (IPL) followed by radiofrequency (RF) on the periocular skin, followed by meibomian gland expression (MGX). The main outcome measure was the quality of meibum in 15 meibomian glands along the lower eyelid, using the modified Meibomian Gland Score (mMGS). The main hypothesis was a reduction of mMGS between the baseline (BL) and the follow-up (FU). Other outcome measures, such as symptoms measured with the OSDI (Ocular Surface Disease Index) questionnaire, meibography, non-invasive tear break-up time (NIBUT), and matrix metallopeptidase 9 (MMP-9) levels in tear samples were evaluated as well. RESULTS: 31 subjects completed the FU. Between BL and FU, mMGS decreased from 30.4 (8.5) to 9.3 (9.5) (−69.3%, 95% CI: −55.6% to −82.9%, p<0.0001); OSDI decreased from 63.6 (17.2) to 25.0 (20.6) (−60.7%, 95% CI: −47.8% to −73.5%, p<0.0001); NIBUT did not change (p=0.92). An adjusted model with a historical control was constructed to allow the comparison of these subjects with those treated similarly with IPL+MGX (but without RF) in a different study. This analysis identified that the change in mMGS was larger when RF was included (−20.9 vs −18.3, adjusted p-value (p_adjusted) <0.05). The difference in OSDI change was not significant (−38.1 vs −25.5, p_adjusted = 0.196). CONCLUSION: Combination of multi-frequency RF and IPL+MGX improves signs and symptoms of MGD. In comparison to a historical control, improvements were generally larger. A randomized controlled study comparing the combination of RF and IPL+MGX with IPL+MGX alone is required to further elaborate the relative contribution of RF.
format Online
Article
Text
id pubmed-10595163
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-105951632023-10-25 Multi-Frequency RF Combined with Intense Pulsed Light Improves Signs and Symptoms of Dry Eye Disease Due to Meibomian Gland Dysfunction Chelnis, James Garcia, Chantel N Hamza, Haya Clin Ophthalmol Clinical Trial Report PURPOSE: To evaluate the efficacy of multi-frequency RF and IPL + MGX combination for treatment of Meibomian Gland Dysfunction (MGD). PATIENTS AND METHODS: Eligible subjects had signs and moderate-to-severe symptoms of DED (Dry Eye Disease) due to MGD. Subjects underwent 4 treatments at 2-week intervals. Each treatment consisted of intense pulsed light (IPL) followed by radiofrequency (RF) on the periocular skin, followed by meibomian gland expression (MGX). The main outcome measure was the quality of meibum in 15 meibomian glands along the lower eyelid, using the modified Meibomian Gland Score (mMGS). The main hypothesis was a reduction of mMGS between the baseline (BL) and the follow-up (FU). Other outcome measures, such as symptoms measured with the OSDI (Ocular Surface Disease Index) questionnaire, meibography, non-invasive tear break-up time (NIBUT), and matrix metallopeptidase 9 (MMP-9) levels in tear samples were evaluated as well. RESULTS: 31 subjects completed the FU. Between BL and FU, mMGS decreased from 30.4 (8.5) to 9.3 (9.5) (−69.3%, 95% CI: −55.6% to −82.9%, p<0.0001); OSDI decreased from 63.6 (17.2) to 25.0 (20.6) (−60.7%, 95% CI: −47.8% to −73.5%, p<0.0001); NIBUT did not change (p=0.92). An adjusted model with a historical control was constructed to allow the comparison of these subjects with those treated similarly with IPL+MGX (but without RF) in a different study. This analysis identified that the change in mMGS was larger when RF was included (−20.9 vs −18.3, adjusted p-value (p_adjusted) <0.05). The difference in OSDI change was not significant (−38.1 vs −25.5, p_adjusted = 0.196). CONCLUSION: Combination of multi-frequency RF and IPL+MGX improves signs and symptoms of MGD. In comparison to a historical control, improvements were generally larger. A randomized controlled study comparing the combination of RF and IPL+MGX with IPL+MGX alone is required to further elaborate the relative contribution of RF. Dove 2023-10-20 /pmc/articles/PMC10595163/ /pubmed/37881780 http://dx.doi.org/10.2147/OPTH.S426564 Text en © 2023 Chelnis et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Clinical Trial Report
Chelnis, James
Garcia, Chantel N
Hamza, Haya
Multi-Frequency RF Combined with Intense Pulsed Light Improves Signs and Symptoms of Dry Eye Disease Due to Meibomian Gland Dysfunction
title Multi-Frequency RF Combined with Intense Pulsed Light Improves Signs and Symptoms of Dry Eye Disease Due to Meibomian Gland Dysfunction
title_full Multi-Frequency RF Combined with Intense Pulsed Light Improves Signs and Symptoms of Dry Eye Disease Due to Meibomian Gland Dysfunction
title_fullStr Multi-Frequency RF Combined with Intense Pulsed Light Improves Signs and Symptoms of Dry Eye Disease Due to Meibomian Gland Dysfunction
title_full_unstemmed Multi-Frequency RF Combined with Intense Pulsed Light Improves Signs and Symptoms of Dry Eye Disease Due to Meibomian Gland Dysfunction
title_short Multi-Frequency RF Combined with Intense Pulsed Light Improves Signs and Symptoms of Dry Eye Disease Due to Meibomian Gland Dysfunction
title_sort multi-frequency rf combined with intense pulsed light improves signs and symptoms of dry eye disease due to meibomian gland dysfunction
topic Clinical Trial Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10595163/
https://www.ncbi.nlm.nih.gov/pubmed/37881780
http://dx.doi.org/10.2147/OPTH.S426564
work_keys_str_mv AT chelnisjames multifrequencyrfcombinedwithintensepulsedlightimprovessignsandsymptomsofdryeyediseaseduetomeibomianglanddysfunction
AT garciachanteln multifrequencyrfcombinedwithintensepulsedlightimprovessignsandsymptomsofdryeyediseaseduetomeibomianglanddysfunction
AT hamzahaya multifrequencyrfcombinedwithintensepulsedlightimprovessignsandsymptomsofdryeyediseaseduetomeibomianglanddysfunction