Cargando…
Effects of Hyperbaric and Isobaric Bupivacaine on Hemodynamic Profiles and Block Characteristics Among Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial
BACKGROUND: Cesarean section (CS) is a surgical procedure where the baby is delivered through incisions made in the abdomen and uterus. Bupivacaine is a widely recognized local anesthetic available in different baricity and it is frequently used for spinal anesthesia. The baricity of bupivacaine imp...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10595164/ https://www.ncbi.nlm.nih.gov/pubmed/37881235 http://dx.doi.org/10.2147/JPR.S428314 |
_version_ | 1785124803793911808 |
---|---|
author | Besha, Aschalew Zemedkun, Abebayehu Tadesse, Muhiddin Hailu, Seyoum Mossie, Addisu Shiferaw, Adanech Angasa, Dugo Adamu, Yayeh |
author_facet | Besha, Aschalew Zemedkun, Abebayehu Tadesse, Muhiddin Hailu, Seyoum Mossie, Addisu Shiferaw, Adanech Angasa, Dugo Adamu, Yayeh |
author_sort | Besha, Aschalew |
collection | PubMed |
description | BACKGROUND: Cesarean section (CS) is a surgical procedure where the baby is delivered through incisions made in the abdomen and uterus. Bupivacaine is a widely recognized local anesthetic available in different baricity and it is frequently used for spinal anesthesia. The baricity of bupivacaine impacts hemodynamic profiles and block characteristics. OBJECTIVE: To compare the effects of hyperbaric and isobaric bupivacaine on hemodynamic profiles and block characteristics among parturients undergoing elective cesarean section under spinal anesthesia at Dilla University Referral Hospital. METHODS: 64 pregnant mothers scheduled for elective cesarean section under spinal anesthesia were randomly assigned to two groups: Group A received a dose of 12.5 mg of isobaric bupivacaine (n = 32), Group B received a dose of 12.5 mg of hyperbaric bupivacaine (n = 32). Prior to conducting the study, the necessary ethical approvals were obtained. For comparing numerical variables between the two groups, the independent Sample t-test or Mann–Whitney U-test was employed as needed. Repeated measurements were analyzed using mixed ANOVA. Categorical variables were assessed using either the chi-square test or Fisher’s exact test. Statistical significance was set at P < 0.05, with a power of 90%. RESULTS: The mean Systolic Blood Pressure (SBP), Diastolic Blood pressure (DBP), and Mean Arterial Blood Pressure (MAP) showed significant decrement in the group receiving isobaric spinal anesthesia compared to those receiving hyperbaric bupivacaine. The decrement was observed from the 6th to 30th minute (p<0.05). Furthermore, the hyperbaric group had a faster onset time for achieving the maximum sensory block, with a median time of 3 (1) min compared to 4 (2) mins in the isobaric group (p<0.001). CONCLUSION AND RECOMMENDATION: We conclude that hyperbaric bupivacaine provides stable intraoperative hemodynamic parameters and an earlier onset of block than isobaric bupivacaine. Therefore, we recommend clinicians to use hyperbaric bupivacaine for cesarean delivery. |
format | Online Article Text |
id | pubmed-10595164 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-105951642023-10-25 Effects of Hyperbaric and Isobaric Bupivacaine on Hemodynamic Profiles and Block Characteristics Among Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial Besha, Aschalew Zemedkun, Abebayehu Tadesse, Muhiddin Hailu, Seyoum Mossie, Addisu Shiferaw, Adanech Angasa, Dugo Adamu, Yayeh J Pain Res Original Research BACKGROUND: Cesarean section (CS) is a surgical procedure where the baby is delivered through incisions made in the abdomen and uterus. Bupivacaine is a widely recognized local anesthetic available in different baricity and it is frequently used for spinal anesthesia. The baricity of bupivacaine impacts hemodynamic profiles and block characteristics. OBJECTIVE: To compare the effects of hyperbaric and isobaric bupivacaine on hemodynamic profiles and block characteristics among parturients undergoing elective cesarean section under spinal anesthesia at Dilla University Referral Hospital. METHODS: 64 pregnant mothers scheduled for elective cesarean section under spinal anesthesia were randomly assigned to two groups: Group A received a dose of 12.5 mg of isobaric bupivacaine (n = 32), Group B received a dose of 12.5 mg of hyperbaric bupivacaine (n = 32). Prior to conducting the study, the necessary ethical approvals were obtained. For comparing numerical variables between the two groups, the independent Sample t-test or Mann–Whitney U-test was employed as needed. Repeated measurements were analyzed using mixed ANOVA. Categorical variables were assessed using either the chi-square test or Fisher’s exact test. Statistical significance was set at P < 0.05, with a power of 90%. RESULTS: The mean Systolic Blood Pressure (SBP), Diastolic Blood pressure (DBP), and Mean Arterial Blood Pressure (MAP) showed significant decrement in the group receiving isobaric spinal anesthesia compared to those receiving hyperbaric bupivacaine. The decrement was observed from the 6th to 30th minute (p<0.05). Furthermore, the hyperbaric group had a faster onset time for achieving the maximum sensory block, with a median time of 3 (1) min compared to 4 (2) mins in the isobaric group (p<0.001). CONCLUSION AND RECOMMENDATION: We conclude that hyperbaric bupivacaine provides stable intraoperative hemodynamic parameters and an earlier onset of block than isobaric bupivacaine. Therefore, we recommend clinicians to use hyperbaric bupivacaine for cesarean delivery. Dove 2023-10-20 /pmc/articles/PMC10595164/ /pubmed/37881235 http://dx.doi.org/10.2147/JPR.S428314 Text en © 2023 Besha et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Besha, Aschalew Zemedkun, Abebayehu Tadesse, Muhiddin Hailu, Seyoum Mossie, Addisu Shiferaw, Adanech Angasa, Dugo Adamu, Yayeh Effects of Hyperbaric and Isobaric Bupivacaine on Hemodynamic Profiles and Block Characteristics Among Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial |
title | Effects of Hyperbaric and Isobaric Bupivacaine on Hemodynamic Profiles and Block Characteristics Among Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial |
title_full | Effects of Hyperbaric and Isobaric Bupivacaine on Hemodynamic Profiles and Block Characteristics Among Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial |
title_fullStr | Effects of Hyperbaric and Isobaric Bupivacaine on Hemodynamic Profiles and Block Characteristics Among Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial |
title_full_unstemmed | Effects of Hyperbaric and Isobaric Bupivacaine on Hemodynamic Profiles and Block Characteristics Among Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial |
title_short | Effects of Hyperbaric and Isobaric Bupivacaine on Hemodynamic Profiles and Block Characteristics Among Parturients Undergoing Elective Cesarean Section Under Spinal Anesthesia: A Randomized Controlled Trial |
title_sort | effects of hyperbaric and isobaric bupivacaine on hemodynamic profiles and block characteristics among parturients undergoing elective cesarean section under spinal anesthesia: a randomized controlled trial |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10595164/ https://www.ncbi.nlm.nih.gov/pubmed/37881235 http://dx.doi.org/10.2147/JPR.S428314 |
work_keys_str_mv | AT beshaaschalew effectsofhyperbaricandisobaricbupivacaineonhemodynamicprofilesandblockcharacteristicsamongparturientsundergoingelectivecesareansectionunderspinalanesthesiaarandomizedcontrolledtrial AT zemedkunabebayehu effectsofhyperbaricandisobaricbupivacaineonhemodynamicprofilesandblockcharacteristicsamongparturientsundergoingelectivecesareansectionunderspinalanesthesiaarandomizedcontrolledtrial AT tadessemuhiddin effectsofhyperbaricandisobaricbupivacaineonhemodynamicprofilesandblockcharacteristicsamongparturientsundergoingelectivecesareansectionunderspinalanesthesiaarandomizedcontrolledtrial AT hailuseyoum effectsofhyperbaricandisobaricbupivacaineonhemodynamicprofilesandblockcharacteristicsamongparturientsundergoingelectivecesareansectionunderspinalanesthesiaarandomizedcontrolledtrial AT mossieaddisu effectsofhyperbaricandisobaricbupivacaineonhemodynamicprofilesandblockcharacteristicsamongparturientsundergoingelectivecesareansectionunderspinalanesthesiaarandomizedcontrolledtrial AT shiferawadanech effectsofhyperbaricandisobaricbupivacaineonhemodynamicprofilesandblockcharacteristicsamongparturientsundergoingelectivecesareansectionunderspinalanesthesiaarandomizedcontrolledtrial AT angasadugo effectsofhyperbaricandisobaricbupivacaineonhemodynamicprofilesandblockcharacteristicsamongparturientsundergoingelectivecesareansectionunderspinalanesthesiaarandomizedcontrolledtrial AT adamuyayeh effectsofhyperbaricandisobaricbupivacaineonhemodynamicprofilesandblockcharacteristicsamongparturientsundergoingelectivecesareansectionunderspinalanesthesiaarandomizedcontrolledtrial |