Years Lived with Disability due to COVID-19 in the capital of Serbia in 2020 and 2021

BACKGROUND: Valid estimates of the national disease burden often lack during crises. They need to be improved to help assess the effectiveness and efficiency of the national public health system. To determine the magnitude of acute COVID-19 in Belgrade in 2020 and 2021, we estimated the total, age and sex-disaggregated Years Lived with Disability (YLD). METHODS: YLD and YLD/100,000 population due to acute COVID-19 were calculated for Belgrade (Serbia) in 2020 (March 6 - December 31) and 2021 (January 1 - December 31) within the EU COST Action 18218 and the BoCO-19 study. The City Institute of Public Health Belgrade provided surveillance numbers of cases of ICD-X: U07.1 and U07.2 (unknown age cases were proportionally redistributed) and population estimates. Severity weights and length of the disease were taken from the German National Burden of Disease study. RESULTS: In 2020, 33,842 acute COVID-19 cases (50.04% were men) had 73.0 YLD (men: 40.6 YLD or 5.1 YLD /100,000; women: 32.4 YLD or 3.6 YLD/100,000). In 2021, 65,020 COVID-19 cases (54.5% were women) had 130.3 YLD (men: 65.1 YLD or 8.2 YLD /100,000; women: 65.2 YLD or 7.3 YLD/100,000). Mild cases were more often among men 10-19 years and women 35-44 years. Moderate cases were more often among persons 35-44 years. Critical cases were more often among the men. More YLD were estimated for severe cases among women in 2021 than in 2020. CONCLUSIONS: In Belgrade, the YLD burden of acute COVID-19 in 2021 was almost double that of 2020. Women had more often severe forms of acute COVID-19 and more YLD in 2021 than in 2020. Men often had moderate and critical cases of acute COVID-19 and higher YLD rates than women. The COVID-19 pandemic demonstrates the importance of having disease burden metrics to help contextually assess the health system's response to crises. Belgrade-level estimates can also be used for national estimates because of the same case definitions, treatment protocols, and data collection methods. KEY MESSAGES: • The YLD burden of the COVID-19 pandemic in 2021 was almost double that of 2020 for population of Belgrade. • In 2020, higher YLD had men due to critical cases, in 2020, women due to severe cases in 2021 indicating greater exposure of men and greater vulnerability of women.