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Preliminary study on changes in BDNF in patients with depression after percutaneous coronary intervention

INTRODUCTION: Depression and coronary artery disease (CAD) are often comorbid conditions. The presence of depression significantly interferes with the recovery after CAD therapy intervention, such as percutaneous coronary intervention (PCI), one of the most common medical procedures in developed cou...

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Autores principales: Medved, S., Sović, S., Ganoci, L., Božina, N., Šagud, M., Bulum, J., Mihaljević-Peleš, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10596015/
http://dx.doi.org/10.1192/j.eurpsy.2023.232
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author Medved, S.
Sović, S.
Ganoci, L.
Božina, N.
Šagud, M.
Bulum, J.
Mihaljević-Peleš, A.
author_facet Medved, S.
Sović, S.
Ganoci, L.
Božina, N.
Šagud, M.
Bulum, J.
Mihaljević-Peleš, A.
author_sort Medved, S.
collection PubMed
description INTRODUCTION: Depression and coronary artery disease (CAD) are often comorbid conditions. The presence of depression significantly interferes with the recovery after CAD therapy intervention, such as percutaneous coronary intervention (PCI), one of the most common medical procedures in developed countries. Brain derived neurotrophic factor (BDNF) has a major role in angiogenesis and neuromodulation. Its levels were previously shown to be reduced in patients with depression, and latest studies indicate similar in patients with CAD. However, the correlation of BDNF levels and depression after CAD treatment is unknown. OBJECTIVES: The aim of this preliminary study is to assess the changes in BDNF levels in patients with depressive symptoms during a six-month period upon PCI. METHODS: Antidepressant-free participants that underwent PCI with stent placement due to myocardial infarction or angina pectoris were enrolled in the study. Depressive symptoms were evaluated at baseline using the Beck’s Depression Inventory II (BDI-II) with a cut-off score ≥20 indicating moderate depression. Serum BDNF levels were measured from blood samples drawn a day after (baseline) and six-months upon a successful PCI without complications. The t-test for dependent samples was used with marked significant differences at p<0,05. RESULTS: Altogether, 76 participants were included in the study, of which 25 finished a six-month follow-up. Participants with BDI-II≥20 at baseline had higher serum BDNF levels in the second measurement (M=23,12, SD=6,20; M=32,02, SD=12,26, respectively). No significant difference was found in serum BDNF levels in measurements between participants with and without depressive symptoms (t=0,33, p=0,74; t=-1,40, p=0,18, respectively). Statistically significant difference was found between serum BDNF in the first and second measurement in the overall sample (t=-2,28, p=0,03) and in participants with baseline moderate depressive symptoms (t=-2,46, p= 0,03), but not in those without (t=-0,59, p=0,57). CONCLUSIONS: Serum BDNF levels in participants with baseline moderate depressive symptoms increased after a six-month period upon successful PCI treatment, whereas that trend was not observed in participants without depressive symptoms. This highlights the potential synergistic role of BDNF in comorbid depression and CAD. DISCLOSURE OF INTEREST: None Declared
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spelling pubmed-105960152023-10-25 Preliminary study on changes in BDNF in patients with depression after percutaneous coronary intervention Medved, S. Sović, S. Ganoci, L. Božina, N. Šagud, M. Bulum, J. Mihaljević-Peleš, A. Eur Psychiatry Abstract INTRODUCTION: Depression and coronary artery disease (CAD) are often comorbid conditions. The presence of depression significantly interferes with the recovery after CAD therapy intervention, such as percutaneous coronary intervention (PCI), one of the most common medical procedures in developed countries. Brain derived neurotrophic factor (BDNF) has a major role in angiogenesis and neuromodulation. Its levels were previously shown to be reduced in patients with depression, and latest studies indicate similar in patients with CAD. However, the correlation of BDNF levels and depression after CAD treatment is unknown. OBJECTIVES: The aim of this preliminary study is to assess the changes in BDNF levels in patients with depressive symptoms during a six-month period upon PCI. METHODS: Antidepressant-free participants that underwent PCI with stent placement due to myocardial infarction or angina pectoris were enrolled in the study. Depressive symptoms were evaluated at baseline using the Beck’s Depression Inventory II (BDI-II) with a cut-off score ≥20 indicating moderate depression. Serum BDNF levels were measured from blood samples drawn a day after (baseline) and six-months upon a successful PCI without complications. The t-test for dependent samples was used with marked significant differences at p<0,05. RESULTS: Altogether, 76 participants were included in the study, of which 25 finished a six-month follow-up. Participants with BDI-II≥20 at baseline had higher serum BDNF levels in the second measurement (M=23,12, SD=6,20; M=32,02, SD=12,26, respectively). No significant difference was found in serum BDNF levels in measurements between participants with and without depressive symptoms (t=0,33, p=0,74; t=-1,40, p=0,18, respectively). Statistically significant difference was found between serum BDNF in the first and second measurement in the overall sample (t=-2,28, p=0,03) and in participants with baseline moderate depressive symptoms (t=-2,46, p= 0,03), but not in those without (t=-0,59, p=0,57). CONCLUSIONS: Serum BDNF levels in participants with baseline moderate depressive symptoms increased after a six-month period upon successful PCI treatment, whereas that trend was not observed in participants without depressive symptoms. This highlights the potential synergistic role of BDNF in comorbid depression and CAD. DISCLOSURE OF INTEREST: None Declared Cambridge University Press 2023-07-19 /pmc/articles/PMC10596015/ http://dx.doi.org/10.1192/j.eurpsy.2023.232 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Medved, S.
Sović, S.
Ganoci, L.
Božina, N.
Šagud, M.
Bulum, J.
Mihaljević-Peleš, A.
Preliminary study on changes in BDNF in patients with depression after percutaneous coronary intervention
title Preliminary study on changes in BDNF in patients with depression after percutaneous coronary intervention
title_full Preliminary study on changes in BDNF in patients with depression after percutaneous coronary intervention
title_fullStr Preliminary study on changes in BDNF in patients with depression after percutaneous coronary intervention
title_full_unstemmed Preliminary study on changes in BDNF in patients with depression after percutaneous coronary intervention
title_short Preliminary study on changes in BDNF in patients with depression after percutaneous coronary intervention
title_sort preliminary study on changes in bdnf in patients with depression after percutaneous coronary intervention
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10596015/
http://dx.doi.org/10.1192/j.eurpsy.2023.232
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