Cargando…

Quantitative electroencephalogram study in patients with schizophrenia : a literature review

INTRODUCTION: There has been a continuous effort to discover and specify the neural correlates of schizophrenia (SCZ) based on spontaneous electroencephalogram (EEG) records. Besides contributing to a more effective diagnosis, biomarkers can be crucial to SCZ to hope for therapeutic progress. OBJECT...

Descripción completa

Detalles Bibliográficos
Autores principales: Jardak, D., Smaoui, N., Triki, L., Mnif, M., Gassara, I., Feki, R., Maalej, M., Charfi, N., Ben thabet, J., Zouari, L., Omri, S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10596353/
http://dx.doi.org/10.1192/j.eurpsy.2023.592
_version_ 1785125084324691968
author Jardak, D.
Smaoui, N.
Triki, L.
Mnif, M.
Gassara, I.
Feki, R.
Maalej, M.
Charfi, N.
Ben thabet, J.
Zouari, L.
Omri, S.
Maalej, M.
author_facet Jardak, D.
Smaoui, N.
Triki, L.
Mnif, M.
Gassara, I.
Feki, R.
Maalej, M.
Charfi, N.
Ben thabet, J.
Zouari, L.
Omri, S.
Maalej, M.
author_sort Jardak, D.
collection PubMed
description INTRODUCTION: There has been a continuous effort to discover and specify the neural correlates of schizophrenia (SCZ) based on spontaneous electroencephalogram (EEG) records. Besides contributing to a more effective diagnosis, biomarkers can be crucial to SCZ to hope for therapeutic progress. OBJECTIVES: a literature review was conducted to ascertain whether or not quantitative EEG spectral abnormalities are consistent enough to warrant additional effort towards developing them into a clinical diagnostic test for schizophrenia. METHODS: A systematic search of the databases , ScienceDirect, and PubMed was conducted using the following words : schizophrenia, electroencephalography, neurobiology. The Preferred Items Reporting for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in the construction of this literature review. Primary research articles that reported descriptive EEG results, included comparisons of subjects with and without antipsychotic therapy, and excluded patients with epilepsy were included in the analysis. We analyzed pooled data, where possible, from studies with a similar intervention and methodology. RESULTS: Our study included 11 articles on quantitative EEG changes in schizophrenic patients divided as follows: 2 articles on the genetics of SCZ and EEG data, 3 articles on the psychopathology of SCZ and EEG data, 2 articles on hemispheric coherence, and finally 4 articles on the effect of treatment on EEG.Increased beta activity can be considered as an inherited feature of SCZ. Elevated delta/theta and gamma activity may serve as a specific biomarker for this condition. The delta wave may be a neurophysiological tool to differentiate between negative and positive forms of SCZ.EEG tracings of schizophrenic patients showed increased intra- and inter-hemispheric coherence compared to healthy subjects. Treatment with an antipsychotic drug was associated with a more marked increase in frequency bands in patients receiving an atypical antipsychotic drug. CONCLUSIONS: It is important to study the electroencephalographic changes not only to better understand the etiopathogenesis of SCZ, but also to search for specific physiological biomarkers. DISCLOSURE OF INTEREST: None Declared
format Online
Article
Text
id pubmed-10596353
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Cambridge University Press
record_format MEDLINE/PubMed
spelling pubmed-105963532023-10-25 Quantitative electroencephalogram study in patients with schizophrenia : a literature review Jardak, D. Smaoui, N. Triki, L. Mnif, M. Gassara, I. Feki, R. Maalej, M. Charfi, N. Ben thabet, J. Zouari, L. Omri, S. Maalej, M. Eur Psychiatry Abstract INTRODUCTION: There has been a continuous effort to discover and specify the neural correlates of schizophrenia (SCZ) based on spontaneous electroencephalogram (EEG) records. Besides contributing to a more effective diagnosis, biomarkers can be crucial to SCZ to hope for therapeutic progress. OBJECTIVES: a literature review was conducted to ascertain whether or not quantitative EEG spectral abnormalities are consistent enough to warrant additional effort towards developing them into a clinical diagnostic test for schizophrenia. METHODS: A systematic search of the databases , ScienceDirect, and PubMed was conducted using the following words : schizophrenia, electroencephalography, neurobiology. The Preferred Items Reporting for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed in the construction of this literature review. Primary research articles that reported descriptive EEG results, included comparisons of subjects with and without antipsychotic therapy, and excluded patients with epilepsy were included in the analysis. We analyzed pooled data, where possible, from studies with a similar intervention and methodology. RESULTS: Our study included 11 articles on quantitative EEG changes in schizophrenic patients divided as follows: 2 articles on the genetics of SCZ and EEG data, 3 articles on the psychopathology of SCZ and EEG data, 2 articles on hemispheric coherence, and finally 4 articles on the effect of treatment on EEG.Increased beta activity can be considered as an inherited feature of SCZ. Elevated delta/theta and gamma activity may serve as a specific biomarker for this condition. The delta wave may be a neurophysiological tool to differentiate between negative and positive forms of SCZ.EEG tracings of schizophrenic patients showed increased intra- and inter-hemispheric coherence compared to healthy subjects. Treatment with an antipsychotic drug was associated with a more marked increase in frequency bands in patients receiving an atypical antipsychotic drug. CONCLUSIONS: It is important to study the electroencephalographic changes not only to better understand the etiopathogenesis of SCZ, but also to search for specific physiological biomarkers. DISCLOSURE OF INTEREST: None Declared Cambridge University Press 2023-07-19 /pmc/articles/PMC10596353/ http://dx.doi.org/10.1192/j.eurpsy.2023.592 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Jardak, D.
Smaoui, N.
Triki, L.
Mnif, M.
Gassara, I.
Feki, R.
Maalej, M.
Charfi, N.
Ben thabet, J.
Zouari, L.
Omri, S.
Maalej, M.
Quantitative electroencephalogram study in patients with schizophrenia : a literature review
title Quantitative electroencephalogram study in patients with schizophrenia : a literature review
title_full Quantitative electroencephalogram study in patients with schizophrenia : a literature review
title_fullStr Quantitative electroencephalogram study in patients with schizophrenia : a literature review
title_full_unstemmed Quantitative electroencephalogram study in patients with schizophrenia : a literature review
title_short Quantitative electroencephalogram study in patients with schizophrenia : a literature review
title_sort quantitative electroencephalogram study in patients with schizophrenia : a literature review
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10596353/
http://dx.doi.org/10.1192/j.eurpsy.2023.592
work_keys_str_mv AT jardakd quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT smaouin quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT trikil quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT mnifm quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT gassarai quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT fekir quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT maalejm quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT charfin quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT benthabetj quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT zouaril quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT omris quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview
AT maalejm quantitativeelectroencephalogramstudyinpatientswithschizophreniaaliteraturereview