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Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: A systematic review and meta-analysis
INTRODUCTION: Weight gain and metabolic disturbances are frequent in people treated with second generation antipsychotics (SGA). OBJECTIVES: We aimed to investigate the effect of SGAs on eating behaviors, cognitions and emotions, as a possible contributor to weight gain and metabolic disturbances. M...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10596423/ http://dx.doi.org/10.1192/j.eurpsy.2023.237 |
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author | Mutwalli, H. Keeler, J. L. Bektas, S. Dhopatkar, N. Treasure, J. Himmerich, H. |
author_facet | Mutwalli, H. Keeler, J. L. Bektas, S. Dhopatkar, N. Treasure, J. Himmerich, H. |
author_sort | Mutwalli, H. |
collection | PubMed |
description | INTRODUCTION: Weight gain and metabolic disturbances are frequent in people treated with second generation antipsychotics (SGA). OBJECTIVES: We aimed to investigate the effect of SGAs on eating behaviors, cognitions and emotions, as a possible contributor to weight gain and metabolic disturbances. METHODS: A systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Original articles measuring outcomes relating to eating cognitions, behaviours and emotions, during treatment with SGAs were included in this review. A total of 92 papers with 11,274 participants were included from three scientific databases (PubMed, Web of Science and PsycInfo). Results were synthesized descriptively except for the continuous data where meta-analyses were performed and for the binary data where odds ratios were calculated. RESULTS: Hunger was increased in participants treated with SGAs with an odds ratio for appetite increase of 1.51 (95% CI [1.04, 1.97]; z=6.40; p<0.001)(see Figure 1.). Compared to controls, our results showed that craving for fat and carbohydrates are the highest among other craving subscales. There was a small increase in dietary disinhibition (SMD=0.40) and restrained eating (SMD=0.43) in participants treated with SGAs compared to controls and substantial heterogeneity across studies reporting these eating traits (See figure 2 and 3). There were few studies examining other eating-related outcomes such as food addiction, satiety, fullness, caloric intake and dietary quality and habits. Image: Image 2: Image 3: CONCLUSIONS: Understanding the mechanisms associated with appetite and eating-related psychopathology changes in patients treated with antipsychotics is needed to reliably inform the development of effective preventative strategies. DISCLOSURE OF INTEREST: H. Mutwalli Grant / Research support from: The Saudi Arabian Government Educational Sponsorship for PhD, J. Keeler Grant / Research support from: The Medical Research Council, S. Bektas Grant / Research support from: The Turkish Ministry of National Education for PhD training, N. Dhopatkar Employee of: South London and Maudsley NHS Foundation Trust (SLaM), J. Treasure Grant / Research support from: The National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at the South London and Maudsley NHS Foundation Trust (SLaM), Employee of: King’s College London, H. Himmerich Grant / Research support from: The National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at the South London and Maudsley NHS Foundation Trust (SLaM), Employee of: King’s College London. |
format | Online Article Text |
id | pubmed-10596423 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105964232023-10-25 Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: A systematic review and meta-analysis Mutwalli, H. Keeler, J. L. Bektas, S. Dhopatkar, N. Treasure, J. Himmerich, H. Eur Psychiatry Abstract INTRODUCTION: Weight gain and metabolic disturbances are frequent in people treated with second generation antipsychotics (SGA). OBJECTIVES: We aimed to investigate the effect of SGAs on eating behaviors, cognitions and emotions, as a possible contributor to weight gain and metabolic disturbances. METHODS: A systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Original articles measuring outcomes relating to eating cognitions, behaviours and emotions, during treatment with SGAs were included in this review. A total of 92 papers with 11,274 participants were included from three scientific databases (PubMed, Web of Science and PsycInfo). Results were synthesized descriptively except for the continuous data where meta-analyses were performed and for the binary data where odds ratios were calculated. RESULTS: Hunger was increased in participants treated with SGAs with an odds ratio for appetite increase of 1.51 (95% CI [1.04, 1.97]; z=6.40; p<0.001)(see Figure 1.). Compared to controls, our results showed that craving for fat and carbohydrates are the highest among other craving subscales. There was a small increase in dietary disinhibition (SMD=0.40) and restrained eating (SMD=0.43) in participants treated with SGAs compared to controls and substantial heterogeneity across studies reporting these eating traits (See figure 2 and 3). There were few studies examining other eating-related outcomes such as food addiction, satiety, fullness, caloric intake and dietary quality and habits. Image: Image 2: Image 3: CONCLUSIONS: Understanding the mechanisms associated with appetite and eating-related psychopathology changes in patients treated with antipsychotics is needed to reliably inform the development of effective preventative strategies. DISCLOSURE OF INTEREST: H. Mutwalli Grant / Research support from: The Saudi Arabian Government Educational Sponsorship for PhD, J. Keeler Grant / Research support from: The Medical Research Council, S. Bektas Grant / Research support from: The Turkish Ministry of National Education for PhD training, N. Dhopatkar Employee of: South London and Maudsley NHS Foundation Trust (SLaM), J. Treasure Grant / Research support from: The National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at the South London and Maudsley NHS Foundation Trust (SLaM), Employee of: King’s College London, H. Himmerich Grant / Research support from: The National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at the South London and Maudsley NHS Foundation Trust (SLaM), Employee of: King’s College London. Cambridge University Press 2023-07-19 /pmc/articles/PMC10596423/ http://dx.doi.org/10.1192/j.eurpsy.2023.237 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstract Mutwalli, H. Keeler, J. L. Bektas, S. Dhopatkar, N. Treasure, J. Himmerich, H. Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: A systematic review and meta-analysis |
title | Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: A systematic review and meta-analysis |
title_full | Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: A systematic review and meta-analysis |
title_fullStr | Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: A systematic review and meta-analysis |
title_full_unstemmed | Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: A systematic review and meta-analysis |
title_short | Eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: A systematic review and meta-analysis |
title_sort | eating cognitions, emotions and behaviour under treatment with second generation antipsychotics: a systematic review and meta-analysis |
topic | Abstract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10596423/ http://dx.doi.org/10.1192/j.eurpsy.2023.237 |
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