A Pilot Study on the Prevalence of Peripheral Arterial Disease in Kigali, Rwanda

BACKGROUND: Peripheral arterial disease (PAD) has significant morbidity including limb loss. The prevalence of PAD in low- and middle-income countries ranges from 3-25% though the global burden is accepted to be near 6%. The objective of this pilot study was to estimate the prevalence of PAD and associated risk factors in Kigali, Rwanda. METHODS: This is a multicenter, mixed-methods, cross-sectional study conducted at three health facilities in Kigali, Rwanda. Patients older than 40 years old presenting for non-emergent reasons at the clinics were eligible for participation in the study. An ankle-brachial index (ABI) was measured using the Unetixs Revo 1100/8 MHz probe for PAD screening. An ABI </=0.9 was the value diagnostic for PAD, and >1.3 was used for an inconclusive ABI. A self-reported survey was collected to determine demographics and medical history, including smoking status and medication use. RESULTS: A total of 861 participants were included in this study with an overall PAD positivity rate of 3.14%. Additionally, 166 patients (19.3%) had inconclusive ABIs. Patients who screened positive for PAD were significantly more likely to be older (63 vs 56, p = 0.009), of lower wealth indexes (p = 0.016), and were more likely to be current or former smokers (13 (48.1%) vs 217 (32.5%), p = 0.041) (Table 1). Patients with inconclusive ABIs were significantly more likely to be male (70 (42%) vs 140 (21%), p = <0.001), more likely to have chronic kidney disease (4 (2.4%) vs 2 (0.3%), p = 0.016), and more likely to be positive for human immunodeficiency virus (HIV) (44 (27%) vs 127 (19%), p = 0.041). There were also lower rates of DM and HTN in the inconclusive group but no differences in the diagnostic group. CONCLUSIONS: Our results revealed that the prevalence of PAD in Kigali, Rwanda, was similar to ranges quoted in the literature at 3.14%. Results hint that traditional risk factors such as DM and HTN may be less common amongst people with PAD in Rwanda. KEY MESSAGES: • The prevalence of peripheral artery disease (PAD) in Rwanda is similar to estimates in other LMICs. • Traditional risk factors such as diabetes and hypertension may play smaller roles in the etiology of peripheral artery disease (PAD) in Rwanda.