Single-Cell RNA Sequencing of Coronary Perivascular Adipose Tissue From End-Stage Heart Failure Patients Identifies SPP1(+) Macrophage Subpopulation as a Target for Alleviating Fibrosis

BACKGROUND: Perivascular adipose tissue (PVAT) is vital for vascular homeostasis, and PVAT dysfunction is associated with increased atherosclerotic plaque burden. But the mechanisms underlining coronary PVAT dysfunction in coronary atherosclerosis remain elusive. METHODS: We performed single-cell RN...

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Detalles Bibliográficos
Autores principales: Fu, Mengxia, Shu, Songren, Peng, Zhiming, Liu, Xiaorui, Chen, Xiao, Zeng, Zhiwei, Yang, Yicheng, Cui, Hao, Zhao, Ruojin, Wang, Xiaohu, Du, Leilei, Wu, Min, Feng, Wei, Song, Jiangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Basic Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597444/
https://www.ncbi.nlm.nih.gov/pubmed/37706320
http://dx.doi.org/10.1161/ATVBAHA.123.319828

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