Natural immunity to malaria preferentially targets the endothelial protein C receptor-binding regions of PfEMP1s

Antibody responses to variant surface antigens (VSAs) produced by the malaria parasite Plasmodium falciparum may contribute to age-related natural immunity to severe malaria. One VSA family, P. falciparum erythrocyte membrane protein-1 (PfEMP1), includes a subset of proteins that binds endothelial p...

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Detalles Bibliográficos
Autores principales: Tewey, Madison A., Coulibaly, Drissa, Lawton, Jonathan G., Stucke, Emily M., Zhou, Albert E., Berry, Andrea A., Bailey, Jason A., Pike, Andrew, Dara, Antoine, Ouattara, Amed, Lyke, Kirsten E., Ifeonu, Olukemi, Laurens, Matthew B., Adams, Matthew, Takala-Harrison, Shannon, Niangaly, Amadou, Kouriba, Bourema, Koné, Abdoulaye K., Rowe, J. Alexandra, Doumbo, Ogobara K., Patel, Jigar J., Tan, John C., Felgner, Philip L., Plowe, Christopher V., Thera, Mahamadou A., Travassos, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597466/
https://www.ncbi.nlm.nih.gov/pubmed/37791774
http://dx.doi.org/10.1128/msphere.00451-23

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