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Mitochondrial pannexin1 controls cardiac sensitivity to ischaemia/reperfusion injury

AIMS: No effective therapy is available in clinics to protect the heart from ischaemia/reperfusion (I/R) injury. Endothelial cells are activated after I/R, which may drive the inflammatory response by releasing ATP through pannexin1 (Panx1) channels. Here, we investigated the role of Panx1 in cardia...

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Detalles Bibliográficos
Autores principales: Rusiecka, Olga M, Molica, Filippo, Nielsen, Morten S, Tollance, Axel, Morel, Sandrine, Frieden, Maud, Chanson, Marc, Boengler, Kerstin, Kwak, Brenda R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597630/
https://www.ncbi.nlm.nih.gov/pubmed/37556386
http://dx.doi.org/10.1093/cvr/cvad120