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The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study

Background: Multiple observational studies have discovered a substantial link between obstructive sleep apnea (OSA) and ventricular dysfunction. However, conventional observational studies are vulnerable to causal reversal and confounding, making it challenging to infer the causes of effects and the...

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Autores principales: Sun, Wanli, Yang, Fan, Yang, Yiyuan, Su, Xin, Xing, Yanwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597648/
https://www.ncbi.nlm.nih.gov/pubmed/37881804
http://dx.doi.org/10.3389/fgene.2023.1266869
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author Sun, Wanli
Yang, Fan
Yang, Yiyuan
Su, Xin
Xing, Yanwei
author_facet Sun, Wanli
Yang, Fan
Yang, Yiyuan
Su, Xin
Xing, Yanwei
author_sort Sun, Wanli
collection PubMed
description Background: Multiple observational studies have discovered a substantial link between obstructive sleep apnea (OSA) and ventricular dysfunction. However, conventional observational studies are vulnerable to causal reversal and confounding, making it challenging to infer the causes of effects and their direction. Methods: With the help of a bidirectional, two-sample Mendelian randomization (MR) study, we assessed the potential causality between OSA and left and right ventricular (LV, RV) structure and function. We conducted our analysis utilizing summary data from genome-wide association studies of OSA (16,761 cases and 201,194 controls) in the FinnGen Study, as well as LV (36,041 participants) and RV (29,506 participants) in the UK Biobank cardiovascular magnetic resonance research. The inverse variance weighted (IVW) was selected as the main strategy, with the MR-Egger and weighted median methods serving as supplements. Other methods were employed as sensitivity analysis tools to look at heterogeneity and pleiotropy, including MR-Egger intercept, Cochran Q statistic, MR-PRESSO, and leave-one-out analysis. Results: In the primary IVW analysis, genetically predicted OSA was strongly causative on LV end-diastolic volume (β = 0.114, 95% CI = 0.034–0.194, p = 0.006) and LV stroke volume (β = 0.111, 95% CI = 0.031–0.191, p = 0.007), and genetically predicted LV ejection fraction was linked to an increased risk of OSA (OR = 1.161, 95% CI = 1.029–1.309, p = 0.015). However, there was no connection found between OSA and any RV parameters. Conclusion: Our genetic analysis raises a potential causative link between OSA and ventricular structure and function, which may improve the knowledge of OSA as a risk factor for cardiovascular disease by demonstrating a direct impact on cardiac structure and function.
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spelling pubmed-105976482023-10-25 The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study Sun, Wanli Yang, Fan Yang, Yiyuan Su, Xin Xing, Yanwei Front Genet Genetics Background: Multiple observational studies have discovered a substantial link between obstructive sleep apnea (OSA) and ventricular dysfunction. However, conventional observational studies are vulnerable to causal reversal and confounding, making it challenging to infer the causes of effects and their direction. Methods: With the help of a bidirectional, two-sample Mendelian randomization (MR) study, we assessed the potential causality between OSA and left and right ventricular (LV, RV) structure and function. We conducted our analysis utilizing summary data from genome-wide association studies of OSA (16,761 cases and 201,194 controls) in the FinnGen Study, as well as LV (36,041 participants) and RV (29,506 participants) in the UK Biobank cardiovascular magnetic resonance research. The inverse variance weighted (IVW) was selected as the main strategy, with the MR-Egger and weighted median methods serving as supplements. Other methods were employed as sensitivity analysis tools to look at heterogeneity and pleiotropy, including MR-Egger intercept, Cochran Q statistic, MR-PRESSO, and leave-one-out analysis. Results: In the primary IVW analysis, genetically predicted OSA was strongly causative on LV end-diastolic volume (β = 0.114, 95% CI = 0.034–0.194, p = 0.006) and LV stroke volume (β = 0.111, 95% CI = 0.031–0.191, p = 0.007), and genetically predicted LV ejection fraction was linked to an increased risk of OSA (OR = 1.161, 95% CI = 1.029–1.309, p = 0.015). However, there was no connection found between OSA and any RV parameters. Conclusion: Our genetic analysis raises a potential causative link between OSA and ventricular structure and function, which may improve the knowledge of OSA as a risk factor for cardiovascular disease by demonstrating a direct impact on cardiac structure and function. Frontiers Media S.A. 2023-10-10 /pmc/articles/PMC10597648/ /pubmed/37881804 http://dx.doi.org/10.3389/fgene.2023.1266869 Text en Copyright © 2023 Sun, Yang, Yang, Su and Xing. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Sun, Wanli
Yang, Fan
Yang, Yiyuan
Su, Xin
Xing, Yanwei
The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study
title The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study
title_full The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study
title_fullStr The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study
title_full_unstemmed The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study
title_short The causality between obstructive sleep apnea and ventricular structure and function: a bidirectional Mendelian randomization study
title_sort causality between obstructive sleep apnea and ventricular structure and function: a bidirectional mendelian randomization study
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597648/
https://www.ncbi.nlm.nih.gov/pubmed/37881804
http://dx.doi.org/10.3389/fgene.2023.1266869
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