Symptom profiles and related factors among patients with advanced cancer: A latent profile analysis

OBJECTIVE: This study aimed to investigate symptom subgroups and associated influencing factors in patients with advanced cancer. METHODS: A cross-sectional study was conducted, involving 416 patients with advanced cancer. The study examined five symptoms: fatigue, pain, sleep impairment, anxiety, and depression. Latent Profile Analysis (LPA) was utilized to classify symptom subgroups. A multiple logistic regression analysis was conducted to explore factors associated with the identified symptom subgroups. RESULTS: The analysis revealed three distinct subgroups among the participants: “all low” (58.2%), characterized by normal symptoms except for moderate sleep quality; “all moderate” (35.1%), exhibiting normal symptoms except for poor sleep quality and fatigue; and “all high” (6.7%), experiencing normal pain, moderate depression, moderate anxiety, poor sleep quality, and fatigue. Malnutrition risk, cancer diagnosis, and cancer survivorship duration were found to be associated with a more severe symptom burden. CONCLUSIONS: Patients in the “all high” subgroup faced an increased risk of malnutrition and a longer cancer survivorship duration. Additionally, patients in the “all moderate” subgroup were distinguished by having a breast cancer diagnosis. These findings have significant implications for allocating medical resources and implementing person-centered symptom management strategies.