Association between depressive and anxious symptoms with cognitive function and quality of life in drug-resistant epilepsy

• Depressive/anxious disorders and cognitive impairment are frequent comorbidities in epilepsy and have a more deleterious effect in DRE. • Studies concerning the relationship between anxiety and depression and cognitive performance in DRE are scarce. • Higher scores in HADS are associated with lower QOLIE-31 scores and might be considered as predictors of QOL in DRE. • A relationship between anxious and depressive symptoms -measured with HADS and SCL-90R- and cognition might not exist. • There remains an unexplored study area regarding this relationship which requires more attention to improve the assessment of DRE.