TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma

Renal cell carcinoma (RCC) occasionally breaches the urothelial tissue barrier and extends into the collecting system mimicking a transitional cell carcinoma. We present a case of a TFE3-rearranged renal cell carcinoma in a young patient that extended to fill the entire upper urinary tract leading t...

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Autores principales: Chacko, Arman Z., Singh, Shweta, Boaz, Johann, Gopinathan, Vikram Raj, Rajadoss, M.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597808/
https://www.ncbi.nlm.nih.gov/pubmed/37886342
http://dx.doi.org/10.1016/j.eucr.2023.102588
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author Chacko, Arman Z.
Singh, Shweta
Boaz, Johann
Gopinathan, Vikram Raj
Rajadoss, M.P.
author_facet Chacko, Arman Z.
Singh, Shweta
Boaz, Johann
Gopinathan, Vikram Raj
Rajadoss, M.P.
author_sort Chacko, Arman Z.
collection PubMed
description Renal cell carcinoma (RCC) occasionally breaches the urothelial tissue barrier and extends into the collecting system mimicking a transitional cell carcinoma. We present a case of a TFE3-rearranged renal cell carcinoma in a young patient that extended to fill the entire upper urinary tract leading to a pre-operative diagnosis of upper tract urothelial carcinoma (UTUC) based on CT imaging. A sequential algorithm of IHC/FISH assays led to the correct diagnosis of TFE3-rearranged RCC. Awareness of this potential misdiagnosis, particularly in young patients, can mitigate significant morbidity.
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spelling pubmed-105978082023-10-26 TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma Chacko, Arman Z. Singh, Shweta Boaz, Johann Gopinathan, Vikram Raj Rajadoss, M.P. Urol Case Rep Oncology Renal cell carcinoma (RCC) occasionally breaches the urothelial tissue barrier and extends into the collecting system mimicking a transitional cell carcinoma. We present a case of a TFE3-rearranged renal cell carcinoma in a young patient that extended to fill the entire upper urinary tract leading to a pre-operative diagnosis of upper tract urothelial carcinoma (UTUC) based on CT imaging. A sequential algorithm of IHC/FISH assays led to the correct diagnosis of TFE3-rearranged RCC. Awareness of this potential misdiagnosis, particularly in young patients, can mitigate significant morbidity. Elsevier 2023-10-15 /pmc/articles/PMC10597808/ /pubmed/37886342 http://dx.doi.org/10.1016/j.eucr.2023.102588 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Oncology
Chacko, Arman Z.
Singh, Shweta
Boaz, Johann
Gopinathan, Vikram Raj
Rajadoss, M.P.
TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma
title TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma
title_full TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma
title_fullStr TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma
title_full_unstemmed TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma
title_short TFE3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma
title_sort tfe3-rearranged renal cell carcinoma with tumour thrombus in the ureter mimicking invasive transitional cell carcinoma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597808/
https://www.ncbi.nlm.nih.gov/pubmed/37886342
http://dx.doi.org/10.1016/j.eucr.2023.102588
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