Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report

A 74-year-old man was referred to our hospital with an abnormal chest shadow. Computed tomography (CT) revealed a mass in the left upper lobe and interstitial pneumonia (IP). The patient underwent CT-guided needle biopsy and was diagnosed as lung adenocarcinoma with cT2aN1M1a Stage IVA (PUL). The pa...

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Autores principales: Okada, Kohei, Sakakibara, Rie, Honda, Takayuki, Mitsumura, Takahiro, Shibata, Sho, Shirai, Tsuyoshi, Okamoto, Tsukasa, Furusawa, Haruhiko, Tateishi, Tomoya, Miyazaki, Yasunari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598048/
https://www.ncbi.nlm.nih.gov/pubmed/37886215
http://dx.doi.org/10.1016/j.rmcr.2023.101929
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author Okada, Kohei
Sakakibara, Rie
Honda, Takayuki
Mitsumura, Takahiro
Shibata, Sho
Shirai, Tsuyoshi
Okamoto, Tsukasa
Furusawa, Haruhiko
Tateishi, Tomoya
Miyazaki, Yasunari
author_facet Okada, Kohei
Sakakibara, Rie
Honda, Takayuki
Mitsumura, Takahiro
Shibata, Sho
Shirai, Tsuyoshi
Okamoto, Tsukasa
Furusawa, Haruhiko
Tateishi, Tomoya
Miyazaki, Yasunari
author_sort Okada, Kohei
collection PubMed
description A 74-year-old man was referred to our hospital with an abnormal chest shadow. Computed tomography (CT) revealed a mass in the left upper lobe and interstitial pneumonia (IP). The patient underwent CT-guided needle biopsy and was diagnosed as lung adenocarcinoma with cT2aN1M1a Stage IVA (PUL). The patient was administered 6 cycles of CBDCA + nab-paclitaxel as first-line, 3 cycles of atezolizumab as second-line, and 8 cycles of S-1 as third-line treatment but finally showed tumor progression. Because comprehensive genome profiling test revealed KRAS G12C mutation, sotorasib was initiated as fourth-line treatment and showed tumor regression without exacerbation of pre-existing IP.
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spelling pubmed-105980482023-10-26 Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report Okada, Kohei Sakakibara, Rie Honda, Takayuki Mitsumura, Takahiro Shibata, Sho Shirai, Tsuyoshi Okamoto, Tsukasa Furusawa, Haruhiko Tateishi, Tomoya Miyazaki, Yasunari Respir Med Case Rep Case Report A 74-year-old man was referred to our hospital with an abnormal chest shadow. Computed tomography (CT) revealed a mass in the left upper lobe and interstitial pneumonia (IP). The patient underwent CT-guided needle biopsy and was diagnosed as lung adenocarcinoma with cT2aN1M1a Stage IVA (PUL). The patient was administered 6 cycles of CBDCA + nab-paclitaxel as first-line, 3 cycles of atezolizumab as second-line, and 8 cycles of S-1 as third-line treatment but finally showed tumor progression. Because comprehensive genome profiling test revealed KRAS G12C mutation, sotorasib was initiated as fourth-line treatment and showed tumor regression without exacerbation of pre-existing IP. Elsevier 2023-10-14 /pmc/articles/PMC10598048/ /pubmed/37886215 http://dx.doi.org/10.1016/j.rmcr.2023.101929 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Okada, Kohei
Sakakibara, Rie
Honda, Takayuki
Mitsumura, Takahiro
Shibata, Sho
Shirai, Tsuyoshi
Okamoto, Tsukasa
Furusawa, Haruhiko
Tateishi, Tomoya
Miyazaki, Yasunari
Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report
title Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report
title_full Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report
title_fullStr Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report
title_full_unstemmed Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report
title_short Tolerability of sotorasib for KRAS positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; A case report
title_sort tolerability of sotorasib for kras positive lung adenocarcinoma patient with pre-existing interstitial pneumonia; a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598048/
https://www.ncbi.nlm.nih.gov/pubmed/37886215
http://dx.doi.org/10.1016/j.rmcr.2023.101929
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