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Drug-related problems in hospitalized patients with type 2 diabetes mellitus: A systematic review

INTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the non-communicable diseases which continues to rise in prevalence and mortality rate throughout the years. Drug-related problems (DRPs) are more prevalent among T2DM patients especially those with co-morbidities. OBJECTIVE: The objective of t...

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Autores principales: Awang Jihadi, Mohammad Hisyamuddin, Yuda, Ana, Sukorini, Anila Impian, Hermansyah, Andi, Shafqat, Naeem, Tan, Ching Siang, Ming, Long Chiau
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598051/
https://www.ncbi.nlm.nih.gov/pubmed/37885436
http://dx.doi.org/10.1016/j.rcsop.2023.100348
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author Awang Jihadi, Mohammad Hisyamuddin
Yuda, Ana
Sukorini, Anila Impian
Hermansyah, Andi
Shafqat, Naeem
Tan, Ching Siang
Ming, Long Chiau
author_facet Awang Jihadi, Mohammad Hisyamuddin
Yuda, Ana
Sukorini, Anila Impian
Hermansyah, Andi
Shafqat, Naeem
Tan, Ching Siang
Ming, Long Chiau
author_sort Awang Jihadi, Mohammad Hisyamuddin
collection PubMed
description INTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the non-communicable diseases which continues to rise in prevalence and mortality rate throughout the years. Drug-related problems (DRPs) are more prevalent among T2DM patients especially those with co-morbidities. OBJECTIVE: The objective of this study was to review and assess the prevalence and characteristics of DRPs among hospitalized type 2 diabetes mellitus patients. METHODS: The systematic review of the literature was carried out using five online databases: PubMed, Scopus, Google Scholar, Web of Science, and Cochrane Library from the inception of the database until June 2022. Studies included in the review were published in English or Malay language. The data were extracted and assessed using the Joanna Briggs Institute (JBI) critical appraisal tools. RESULTS: A total of 939 studies were identified with 20 studies that met inclusion criteria and were included in this systematic review. The overall prevalence of DRPs in all 20 studies ranged from 7% to 94%. The most common DRPs included drug-drug interaction (DDI), adverse drug reaction (ADR), therapeutic effectiveness problems, and inappropriate medication use. CONCLUSION: The most common drug classes involved were antidiabetics (metformin), antihypertensives, antiplatelets and antibiotics. The risk factors contributing to DRPs included the presence of comorbidities, the number of medications, and polypharmacy. To conclude, the rate of DRPs incidence in hospitalized T2DM patients was observed to be high. Further future studies with appropriate study designs and methods of detecting DRPs will be necessary to reduce and prevent DRPs occurrences.
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spelling pubmed-105980512023-10-26 Drug-related problems in hospitalized patients with type 2 diabetes mellitus: A systematic review Awang Jihadi, Mohammad Hisyamuddin Yuda, Ana Sukorini, Anila Impian Hermansyah, Andi Shafqat, Naeem Tan, Ching Siang Ming, Long Chiau Explor Res Clin Soc Pharm Article INTRODUCTION: Type 2 diabetes mellitus (T2DM) is one of the non-communicable diseases which continues to rise in prevalence and mortality rate throughout the years. Drug-related problems (DRPs) are more prevalent among T2DM patients especially those with co-morbidities. OBJECTIVE: The objective of this study was to review and assess the prevalence and characteristics of DRPs among hospitalized type 2 diabetes mellitus patients. METHODS: The systematic review of the literature was carried out using five online databases: PubMed, Scopus, Google Scholar, Web of Science, and Cochrane Library from the inception of the database until June 2022. Studies included in the review were published in English or Malay language. The data were extracted and assessed using the Joanna Briggs Institute (JBI) critical appraisal tools. RESULTS: A total of 939 studies were identified with 20 studies that met inclusion criteria and were included in this systematic review. The overall prevalence of DRPs in all 20 studies ranged from 7% to 94%. The most common DRPs included drug-drug interaction (DDI), adverse drug reaction (ADR), therapeutic effectiveness problems, and inappropriate medication use. CONCLUSION: The most common drug classes involved were antidiabetics (metformin), antihypertensives, antiplatelets and antibiotics. The risk factors contributing to DRPs included the presence of comorbidities, the number of medications, and polypharmacy. To conclude, the rate of DRPs incidence in hospitalized T2DM patients was observed to be high. Further future studies with appropriate study designs and methods of detecting DRPs will be necessary to reduce and prevent DRPs occurrences. Elsevier 2023-10-12 /pmc/articles/PMC10598051/ /pubmed/37885436 http://dx.doi.org/10.1016/j.rcsop.2023.100348 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Awang Jihadi, Mohammad Hisyamuddin
Yuda, Ana
Sukorini, Anila Impian
Hermansyah, Andi
Shafqat, Naeem
Tan, Ching Siang
Ming, Long Chiau
Drug-related problems in hospitalized patients with type 2 diabetes mellitus: A systematic review
title Drug-related problems in hospitalized patients with type 2 diabetes mellitus: A systematic review
title_full Drug-related problems in hospitalized patients with type 2 diabetes mellitus: A systematic review
title_fullStr Drug-related problems in hospitalized patients with type 2 diabetes mellitus: A systematic review
title_full_unstemmed Drug-related problems in hospitalized patients with type 2 diabetes mellitus: A systematic review
title_short Drug-related problems in hospitalized patients with type 2 diabetes mellitus: A systematic review
title_sort drug-related problems in hospitalized patients with type 2 diabetes mellitus: a systematic review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598051/
https://www.ncbi.nlm.nih.gov/pubmed/37885436
http://dx.doi.org/10.1016/j.rcsop.2023.100348
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