Prediction of Knee Joint Compartmental Loading Maxima Utilizing Simple Subject Characteristics and Neural Networks

Joint loading may affect the development of osteoarthritis, but patient-specific load estimation requires cumbersome motion laboratory equipment. This reliance could be eliminated using artificial neural networks (ANNs) to predict loading from simple input predictors. We used subject-specific musculoskeletal simulations to estimate knee joint contact forces for 290 subjects during over 5000 stance phases of walking and then extracted compartmental and total joint loading maxima from the first and second peaks of the stance phase. We then trained ANN models to predict the loading maxima from predictors that can be measured without motion laboratory equipment (subject mass, height, age, gender, knee abduction-adduction angle, and walking speed). When compared to the target data, our trained models had NRMSEs (RMSEs normalized to the mean of the response variable) between 0.14 and 0.42 and Pearson correlation coefficients between 0.42 and 0.84. The loading maxima were predicted most accurately using the models trained with all predictors. We demonstrated that prediction of knee joint loading maxima may be possible without laboratory-measured motion capture data. This is a promising step in facilitating knee joint loading predictions in simple environments, such as a physician’s appointment. In future, the rapid measurement and analysis setup could be utilized to guide patients in rehabilitation to slow development of joint disorders, such as osteoarthritis. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10439-023-03278-y.