Cargando…

Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities

PURPOSE: The aim of this study was to evaluate interobserver agreement (IOA) on target volume definition for pancreatic cancer (PACA) within the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Society of Radiation Oncology (DEGRO) and to identify the influence of imaging modal...

Descripción completa

Detalles Bibliográficos
Autores principales: Gkika, E., Kostyszyn, D., Fechter, T., Moustakis, C., Ernst, F., Boda-Heggemann, J., Sarria, G., Dieckmann, K., Dobiasch, S., Duma, M. N., Eberle, F., Kroeger, K., Häussler, B., Izaguirre, V., Jazmati, D., Lautenschläger, S., Lohaus, F., Mantel, F., Menzel, J., Pachmann, S., Pavic, M., Radlanski, K., Riesterer, O., Gerum, S., Röder, F., Willner, J., Barczyk, S., Imhoff, D., Blanck, O., Wittig, A., Guckenberger, M., Grosu, Anca-L., Brunner, T. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598103/
https://www.ncbi.nlm.nih.gov/pubmed/37268767
http://dx.doi.org/10.1007/s00066-023-02085-7
_version_ 1785125480764014592
author Gkika, E.
Kostyszyn, D.
Fechter, T.
Moustakis, C.
Ernst, F.
Boda-Heggemann, J.
Sarria, G.
Dieckmann, K.
Dobiasch, S.
Duma, M. N.
Eberle, F.
Kroeger, K.
Häussler, B.
Izaguirre, V.
Jazmati, D.
Lautenschläger, S.
Lohaus, F.
Mantel, F.
Menzel, J.
Pachmann, S.
Pavic, M.
Radlanski, K.
Riesterer, O.
Gerum, S.
Röder, F.
Willner, J.
Barczyk, S.
Imhoff, D.
Blanck, O.
Wittig, A.
Guckenberger, M.
Grosu, Anca-L.
Brunner, T. B.
author_facet Gkika, E.
Kostyszyn, D.
Fechter, T.
Moustakis, C.
Ernst, F.
Boda-Heggemann, J.
Sarria, G.
Dieckmann, K.
Dobiasch, S.
Duma, M. N.
Eberle, F.
Kroeger, K.
Häussler, B.
Izaguirre, V.
Jazmati, D.
Lautenschläger, S.
Lohaus, F.
Mantel, F.
Menzel, J.
Pachmann, S.
Pavic, M.
Radlanski, K.
Riesterer, O.
Gerum, S.
Röder, F.
Willner, J.
Barczyk, S.
Imhoff, D.
Blanck, O.
Wittig, A.
Guckenberger, M.
Grosu, Anca-L.
Brunner, T. B.
author_sort Gkika, E.
collection PubMed
description PURPOSE: The aim of this study was to evaluate interobserver agreement (IOA) on target volume definition for pancreatic cancer (PACA) within the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Society of Radiation Oncology (DEGRO) and to identify the influence of imaging modalities on the definition of the target volumes. METHODS: Two cases of locally advanced PACA and one local recurrence were selected from a large SBRT database. Delineation was based on either a planning 4D CT with or without (w/wo) IV contrast, w/wo PET/CT, and w/wo diagnostic MRI. Novel compared to other studies, a combination of four metrics was used to integrate several aspects of target volume segmentation: the Dice coefficient (DSC), the Hausdorff distance (HD), the probabilistic distance (PBD), and the volumetric similarity (VS). RESULTS: For all three GTVs, the median DSC was 0.75 (range 0.17–0.95), the median HD 15 (range 3.22–67.11) mm, the median PBD 0.33 (range 0.06–4.86), and the median VS was 0.88 (range 0.31–1). For ITVs and PTVs the results were similar. When comparing the imaging modalities for delineation, the best agreement for the GTV was achieved using PET/CT, and for the ITV and PTV using 4D PET/CT, in treatment position with abdominal compression. CONCLUSION: Overall, there was good GTV agreement (DSC). Combined metrics appeared to allow a more valid detection of interobserver variation. For SBRT, either 4D PET/CT or 3D PET/CT in treatment position with abdominal compression leads to better agreement and should be considered as a very useful imaging modality for the definition of treatment volumes in pancreatic SBRT. Contouring does not appear to be the weakest link in the treatment planning chain of SBRT for PACA.
format Online
Article
Text
id pubmed-10598103
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer Berlin Heidelberg
record_format MEDLINE/PubMed
spelling pubmed-105981032023-10-26 Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities Gkika, E. Kostyszyn, D. Fechter, T. Moustakis, C. Ernst, F. Boda-Heggemann, J. Sarria, G. Dieckmann, K. Dobiasch, S. Duma, M. N. Eberle, F. Kroeger, K. Häussler, B. Izaguirre, V. Jazmati, D. Lautenschläger, S. Lohaus, F. Mantel, F. Menzel, J. Pachmann, S. Pavic, M. Radlanski, K. Riesterer, O. Gerum, S. Röder, F. Willner, J. Barczyk, S. Imhoff, D. Blanck, O. Wittig, A. Guckenberger, M. Grosu, Anca-L. Brunner, T. B. Strahlenther Onkol Original Article PURPOSE: The aim of this study was to evaluate interobserver agreement (IOA) on target volume definition for pancreatic cancer (PACA) within the Radiosurgery and Stereotactic Radiotherapy Working Group of the German Society of Radiation Oncology (DEGRO) and to identify the influence of imaging modalities on the definition of the target volumes. METHODS: Two cases of locally advanced PACA and one local recurrence were selected from a large SBRT database. Delineation was based on either a planning 4D CT with or without (w/wo) IV contrast, w/wo PET/CT, and w/wo diagnostic MRI. Novel compared to other studies, a combination of four metrics was used to integrate several aspects of target volume segmentation: the Dice coefficient (DSC), the Hausdorff distance (HD), the probabilistic distance (PBD), and the volumetric similarity (VS). RESULTS: For all three GTVs, the median DSC was 0.75 (range 0.17–0.95), the median HD 15 (range 3.22–67.11) mm, the median PBD 0.33 (range 0.06–4.86), and the median VS was 0.88 (range 0.31–1). For ITVs and PTVs the results were similar. When comparing the imaging modalities for delineation, the best agreement for the GTV was achieved using PET/CT, and for the ITV and PTV using 4D PET/CT, in treatment position with abdominal compression. CONCLUSION: Overall, there was good GTV agreement (DSC). Combined metrics appeared to allow a more valid detection of interobserver variation. For SBRT, either 4D PET/CT or 3D PET/CT in treatment position with abdominal compression leads to better agreement and should be considered as a very useful imaging modality for the definition of treatment volumes in pancreatic SBRT. Contouring does not appear to be the weakest link in the treatment planning chain of SBRT for PACA. Springer Berlin Heidelberg 2023-06-02 2023 /pmc/articles/PMC10598103/ /pubmed/37268767 http://dx.doi.org/10.1007/s00066-023-02085-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Gkika, E.
Kostyszyn, D.
Fechter, T.
Moustakis, C.
Ernst, F.
Boda-Heggemann, J.
Sarria, G.
Dieckmann, K.
Dobiasch, S.
Duma, M. N.
Eberle, F.
Kroeger, K.
Häussler, B.
Izaguirre, V.
Jazmati, D.
Lautenschläger, S.
Lohaus, F.
Mantel, F.
Menzel, J.
Pachmann, S.
Pavic, M.
Radlanski, K.
Riesterer, O.
Gerum, S.
Röder, F.
Willner, J.
Barczyk, S.
Imhoff, D.
Blanck, O.
Wittig, A.
Guckenberger, M.
Grosu, Anca-L.
Brunner, T. B.
Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities
title Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities
title_full Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities
title_fullStr Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities
title_full_unstemmed Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities
title_short Interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities
title_sort interobserver agreement on definition of the target volume in stereotactic radiotherapy for pancreatic adenocarcinoma using different imaging modalities
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598103/
https://www.ncbi.nlm.nih.gov/pubmed/37268767
http://dx.doi.org/10.1007/s00066-023-02085-7
work_keys_str_mv AT gkikae interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT kostyszynd interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT fechtert interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT moustakisc interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT ernstf interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT bodaheggemannj interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT sarriag interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT dieckmannk interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT dobiaschs interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT dumamn interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT eberlef interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT kroegerk interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT hausslerb interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT izaguirrev interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT jazmatid interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT lautenschlagers interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT lohausf interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT mantelf interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT menzelj interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT pachmanns interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT pavicm interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT radlanskik interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT riesterero interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT gerums interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT roderf interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT willnerj interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT barczyks interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT imhoffd interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT blancko interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT wittiga interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT guckenbergerm interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT grosuancal interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities
AT brunnertb interobserveragreementondefinitionofthetargetvolumeinstereotacticradiotherapyforpancreaticadenocarcinomausingdifferentimagingmodalities