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Neurotoxin-Derived Optical Probes for Biological and Medical Imaging
The superb specificity and potency of biological toxins targeting various ion channels and receptors are of major interest for the delivery of therapeutics to distinct cell types and subcellular compartments. Fused with reporter proteins or labelled with fluorophores and nanocomposites, animal toxin...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598172/ https://www.ncbi.nlm.nih.gov/pubmed/37468801 http://dx.doi.org/10.1007/s11307-023-01838-1 |
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author | Ergen, Pinar Helin Shorter, Susan Ntziachristos, Vasilis Ovsepian, Saak Victor |
author_facet | Ergen, Pinar Helin Shorter, Susan Ntziachristos, Vasilis Ovsepian, Saak Victor |
author_sort | Ergen, Pinar Helin |
collection | PubMed |
description | The superb specificity and potency of biological toxins targeting various ion channels and receptors are of major interest for the delivery of therapeutics to distinct cell types and subcellular compartments. Fused with reporter proteins or labelled with fluorophores and nanocomposites, animal toxins and their detoxified variants also offer expanding opportunities for visualisation of a range of molecular processes and functions in preclinical models, as well as clinical studies. This article presents state-of-the-art optical probes derived from neurotoxins targeting ion channels, with discussions of their applications in basic and translational biomedical research. It describes the design and production of probes and reviews their applications with advantages and limitations, with prospects for future improvements. Given the advances in imaging tools and expanding research areas benefiting from the use of optical probes, described here resources should assist the discovery process and facilitate high-precision interrogation and therapeutic interventions. |
format | Online Article Text |
id | pubmed-10598172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-105981722023-10-26 Neurotoxin-Derived Optical Probes for Biological and Medical Imaging Ergen, Pinar Helin Shorter, Susan Ntziachristos, Vasilis Ovsepian, Saak Victor Mol Imaging Biol Review Article The superb specificity and potency of biological toxins targeting various ion channels and receptors are of major interest for the delivery of therapeutics to distinct cell types and subcellular compartments. Fused with reporter proteins or labelled with fluorophores and nanocomposites, animal toxins and their detoxified variants also offer expanding opportunities for visualisation of a range of molecular processes and functions in preclinical models, as well as clinical studies. This article presents state-of-the-art optical probes derived from neurotoxins targeting ion channels, with discussions of their applications in basic and translational biomedical research. It describes the design and production of probes and reviews their applications with advantages and limitations, with prospects for future improvements. Given the advances in imaging tools and expanding research areas benefiting from the use of optical probes, described here resources should assist the discovery process and facilitate high-precision interrogation and therapeutic interventions. Springer International Publishing 2023-07-19 2023 /pmc/articles/PMC10598172/ /pubmed/37468801 http://dx.doi.org/10.1007/s11307-023-01838-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Ergen, Pinar Helin Shorter, Susan Ntziachristos, Vasilis Ovsepian, Saak Victor Neurotoxin-Derived Optical Probes for Biological and Medical Imaging |
title | Neurotoxin-Derived Optical Probes for Biological and Medical Imaging |
title_full | Neurotoxin-Derived Optical Probes for Biological and Medical Imaging |
title_fullStr | Neurotoxin-Derived Optical Probes for Biological and Medical Imaging |
title_full_unstemmed | Neurotoxin-Derived Optical Probes for Biological and Medical Imaging |
title_short | Neurotoxin-Derived Optical Probes for Biological and Medical Imaging |
title_sort | neurotoxin-derived optical probes for biological and medical imaging |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598172/ https://www.ncbi.nlm.nih.gov/pubmed/37468801 http://dx.doi.org/10.1007/s11307-023-01838-1 |
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