Healthy aging—would cytotoxic T lymphocytes stand out?

Senescent cells (SnCs) accumulate in multiple tissue types with the process of individual aging, hindering tissue renewal and driving multiple aging-related disorders. Aside from senescence-associated secretory phenotype (SASP) neutralization and senolytics, there is an emerging senolysis strategy t...

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Detalles Bibliográficos
Autores principales: Zhang, Tianyu, Zhang, Jinjin, Wang, Shixuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598194/
https://www.ncbi.nlm.nih.gov/pubmed/37875495
http://dx.doi.org/10.1038/s41420-023-01699-1
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author Zhang, Tianyu
Zhang, Jinjin
Wang, Shixuan
author_facet Zhang, Tianyu
Zhang, Jinjin
Wang, Shixuan
author_sort Zhang, Tianyu
collection PubMed
description Senescent cells (SnCs) accumulate in multiple tissue types with the process of individual aging, hindering tissue renewal and driving multiple aging-related disorders. Aside from senescence-associated secretory phenotype (SASP) neutralization and senolytics, there is an emerging senolysis strategy to eliminate SnCs by mobilizing the immunosurveillance function of cytotoxic T lymphocytes (CTLs).
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spelling pubmed-105981942023-10-26 Healthy aging—would cytotoxic T lymphocytes stand out? Zhang, Tianyu Zhang, Jinjin Wang, Shixuan Cell Death Discov Comment Senescent cells (SnCs) accumulate in multiple tissue types with the process of individual aging, hindering tissue renewal and driving multiple aging-related disorders. Aside from senescence-associated secretory phenotype (SASP) neutralization and senolytics, there is an emerging senolysis strategy to eliminate SnCs by mobilizing the immunosurveillance function of cytotoxic T lymphocytes (CTLs). Nature Publishing Group UK 2023-10-24 /pmc/articles/PMC10598194/ /pubmed/37875495 http://dx.doi.org/10.1038/s41420-023-01699-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Zhang, Tianyu
Zhang, Jinjin
Wang, Shixuan
Healthy aging—would cytotoxic T lymphocytes stand out?
title Healthy aging—would cytotoxic T lymphocytes stand out?
title_full Healthy aging—would cytotoxic T lymphocytes stand out?
title_fullStr Healthy aging—would cytotoxic T lymphocytes stand out?
title_full_unstemmed Healthy aging—would cytotoxic T lymphocytes stand out?
title_short Healthy aging—would cytotoxic T lymphocytes stand out?
title_sort healthy aging—would cytotoxic t lymphocytes stand out?
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598194/
https://www.ncbi.nlm.nih.gov/pubmed/37875495
http://dx.doi.org/10.1038/s41420-023-01699-1
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