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Higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis

BACKGROUND: Animal organ meat (offal) is a food with high nutrient density that is popular in different parts of the world, but its relationship with nonalcoholic steatohepatitis (NASH) is unclear. We aimed to examine whether daily animal organ meat consumption is associated with the presence of NAS...

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Autores principales: Zhang, Rui, Zhang, Huai, Wang, Yi, Tang, Liang-Jie, Li, Gang, Huang, Ou-Yang, Chen, Sui-Dan, Targher, Giovanni, Byrne, Christopher D., Gu, Bin-Bin, Zheng, Ming-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598295/
https://www.ncbi.nlm.nih.gov/pubmed/37886189
http://dx.doi.org/10.21037/hbsn-21-468
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author Zhang, Rui
Zhang, Huai
Wang, Yi
Tang, Liang-Jie
Li, Gang
Huang, Ou-Yang
Chen, Sui-Dan
Targher, Giovanni
Byrne, Christopher D.
Gu, Bin-Bin
Zheng, Ming-Hua
author_facet Zhang, Rui
Zhang, Huai
Wang, Yi
Tang, Liang-Jie
Li, Gang
Huang, Ou-Yang
Chen, Sui-Dan
Targher, Giovanni
Byrne, Christopher D.
Gu, Bin-Bin
Zheng, Ming-Hua
author_sort Zhang, Rui
collection PubMed
description BACKGROUND: Animal organ meat (offal) is a food with high nutrient density that is popular in different parts of the world, but its relationship with nonalcoholic steatohepatitis (NASH) is unclear. We aimed to examine whether daily animal organ meat consumption is associated with the presence of NASH in individuals with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 136 Chinese adults with biopsy-proven NAFLD were included. Definite NASH was defined as NAFLD activity score ≥4 and at least one point for steatosis, ballooning, and lobular inflammation. Daily animal organ meat consumption was estimated using a self-administered validated food frequency questionnaire. Logistic regression analysis was performed to assess the association between animal organ meat intake and liver disease severity. RESULTS: The 136 participants (80.9% men) of the study had a mean ± standard deviation (SD) age of 39.0±12.5 years and body mass index of 27.4±3.6 kg/m(2). Prevalence of definite NASH was 65.4%. Daily median organ meat consumption was 1.30 g/1,000 kcal. Animal organ meat consumption was inversely associated with the presence of NASH even after adjustment of demographics, lifestyle variables, metabolic and dietary factors, as well as liver fibrosis stage; adjusted-odds ratios (95% confidence intervals) for NASH were 0.15 (0.03, 0.69) for the highest tertile and 0.18 (0.05, 0.70) for the medium tertile, compared to the lowest (reference) tertile of animal organ meat intake (P value for trend =0.024). CONCLUSIONS: Our results suggest for the first time that higher animal organ meat consumption is associated with a lower prevalence of NASH in Chinese individuals with biopsy-proven NAFLD.
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spelling pubmed-105982952023-10-26 Higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis Zhang, Rui Zhang, Huai Wang, Yi Tang, Liang-Jie Li, Gang Huang, Ou-Yang Chen, Sui-Dan Targher, Giovanni Byrne, Christopher D. Gu, Bin-Bin Zheng, Ming-Hua Hepatobiliary Surg Nutr Original Article BACKGROUND: Animal organ meat (offal) is a food with high nutrient density that is popular in different parts of the world, but its relationship with nonalcoholic steatohepatitis (NASH) is unclear. We aimed to examine whether daily animal organ meat consumption is associated with the presence of NASH in individuals with nonalcoholic fatty liver disease (NAFLD). METHODS: A total of 136 Chinese adults with biopsy-proven NAFLD were included. Definite NASH was defined as NAFLD activity score ≥4 and at least one point for steatosis, ballooning, and lobular inflammation. Daily animal organ meat consumption was estimated using a self-administered validated food frequency questionnaire. Logistic regression analysis was performed to assess the association between animal organ meat intake and liver disease severity. RESULTS: The 136 participants (80.9% men) of the study had a mean ± standard deviation (SD) age of 39.0±12.5 years and body mass index of 27.4±3.6 kg/m(2). Prevalence of definite NASH was 65.4%. Daily median organ meat consumption was 1.30 g/1,000 kcal. Animal organ meat consumption was inversely associated with the presence of NASH even after adjustment of demographics, lifestyle variables, metabolic and dietary factors, as well as liver fibrosis stage; adjusted-odds ratios (95% confidence intervals) for NASH were 0.15 (0.03, 0.69) for the highest tertile and 0.18 (0.05, 0.70) for the medium tertile, compared to the lowest (reference) tertile of animal organ meat intake (P value for trend =0.024). CONCLUSIONS: Our results suggest for the first time that higher animal organ meat consumption is associated with a lower prevalence of NASH in Chinese individuals with biopsy-proven NAFLD. AME Publishing Company 2022-06-16 2023-10-01 /pmc/articles/PMC10598295/ /pubmed/37886189 http://dx.doi.org/10.21037/hbsn-21-468 Text en 2023 Hepatobiliary Surgery and Nutrition. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Zhang, Rui
Zhang, Huai
Wang, Yi
Tang, Liang-Jie
Li, Gang
Huang, Ou-Yang
Chen, Sui-Dan
Targher, Giovanni
Byrne, Christopher D.
Gu, Bin-Bin
Zheng, Ming-Hua
Higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis
title Higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis
title_full Higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis
title_fullStr Higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis
title_full_unstemmed Higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis
title_short Higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis
title_sort higher consumption of animal organ meat is associated with a lower prevalence of nonalcoholic steatohepatitis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598295/
https://www.ncbi.nlm.nih.gov/pubmed/37886189
http://dx.doi.org/10.21037/hbsn-21-468
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