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Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes

Pediatric diencephalic tumors represent a histopathologically and molecularly diverse group of neoplasms arising in the central part of the brain and involving eloquent structures, including the hypothalamic-pituitary axis (HPA), optic pathway, thalamus, and pineal gland. Presenting symptoms can inc...

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Autores principales: Cockle, Julia V., Corley, Elizabeth A., Zebian, Bassel, Hettige, Samantha, Vaidya, Sucheta J., Angelini, Paola, Stone, Joanna, Leitch, R Jane, Albanese, Assunta, Mandeville, Henry C., Carceller, Fernando, Marshall, Lynley V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598386/
https://www.ncbi.nlm.nih.gov/pubmed/37886179
http://dx.doi.org/10.3389/fonc.2023.1178553
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author Cockle, Julia V.
Corley, Elizabeth A.
Zebian, Bassel
Hettige, Samantha
Vaidya, Sucheta J.
Angelini, Paola
Stone, Joanna
Leitch, R Jane
Albanese, Assunta
Mandeville, Henry C.
Carceller, Fernando
Marshall, Lynley V.
author_facet Cockle, Julia V.
Corley, Elizabeth A.
Zebian, Bassel
Hettige, Samantha
Vaidya, Sucheta J.
Angelini, Paola
Stone, Joanna
Leitch, R Jane
Albanese, Assunta
Mandeville, Henry C.
Carceller, Fernando
Marshall, Lynley V.
author_sort Cockle, Julia V.
collection PubMed
description Pediatric diencephalic tumors represent a histopathologically and molecularly diverse group of neoplasms arising in the central part of the brain and involving eloquent structures, including the hypothalamic-pituitary axis (HPA), optic pathway, thalamus, and pineal gland. Presenting symptoms can include significant neurological, endocrine, or visual manifestations which may be exacerbated by injudicious intervention. Upfront multidisciplinary assessment and coordinated management is crucial from the outset to ensure best short- and long-term functional outcomes. In this review we discuss the clinical and pathological features of the neoplastic entities arising in this location, and their management. We emphasize a clear move towards ‘function preserving’ diagnostic and therapeutic approaches with novel toxicity-sparing strategies, including targeted therapies.
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spelling pubmed-105983862023-10-26 Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes Cockle, Julia V. Corley, Elizabeth A. Zebian, Bassel Hettige, Samantha Vaidya, Sucheta J. Angelini, Paola Stone, Joanna Leitch, R Jane Albanese, Assunta Mandeville, Henry C. Carceller, Fernando Marshall, Lynley V. Front Oncol Oncology Pediatric diencephalic tumors represent a histopathologically and molecularly diverse group of neoplasms arising in the central part of the brain and involving eloquent structures, including the hypothalamic-pituitary axis (HPA), optic pathway, thalamus, and pineal gland. Presenting symptoms can include significant neurological, endocrine, or visual manifestations which may be exacerbated by injudicious intervention. Upfront multidisciplinary assessment and coordinated management is crucial from the outset to ensure best short- and long-term functional outcomes. In this review we discuss the clinical and pathological features of the neoplastic entities arising in this location, and their management. We emphasize a clear move towards ‘function preserving’ diagnostic and therapeutic approaches with novel toxicity-sparing strategies, including targeted therapies. Frontiers Media S.A. 2023-10-10 /pmc/articles/PMC10598386/ /pubmed/37886179 http://dx.doi.org/10.3389/fonc.2023.1178553 Text en Copyright © 2023 Cockle, Corley, Zebian, Hettige, Vaidya, Angelini, Stone, Leitch, Albanese, Mandeville, Carceller and Marshall https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Cockle, Julia V.
Corley, Elizabeth A.
Zebian, Bassel
Hettige, Samantha
Vaidya, Sucheta J.
Angelini, Paola
Stone, Joanna
Leitch, R Jane
Albanese, Assunta
Mandeville, Henry C.
Carceller, Fernando
Marshall, Lynley V.
Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes
title Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes
title_full Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes
title_fullStr Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes
title_full_unstemmed Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes
title_short Novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes
title_sort novel therapeutic approaches for pediatric diencephalic tumors: improving functional outcomes
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598386/
https://www.ncbi.nlm.nih.gov/pubmed/37886179
http://dx.doi.org/10.3389/fonc.2023.1178553
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