Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response

Since the start of the SARS-CoV-2 pandemic, the rapid replacement of one lineage by another has been observed. Indeed, SARS-CoV-2 is evolving through a quasispecies mechanism leading to post-infection mutation selection under positive evolutionary pressure (host-driven viral evolution). These mutati...

Descripción completa

Detalles Bibliográficos
Autores principales: Devaux, Christian A., Fantini, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598458/
https://www.ncbi.nlm.nih.gov/pubmed/37885880
http://dx.doi.org/10.3389/fimmu.2023.1252367
_version_ 1785125557510340608
author Devaux, Christian A.
Fantini, Jacques
author_facet Devaux, Christian A.
Fantini, Jacques
author_sort Devaux, Christian A.
collection PubMed
description Since the start of the SARS-CoV-2 pandemic, the rapid replacement of one lineage by another has been observed. Indeed, SARS-CoV-2 is evolving through a quasispecies mechanism leading to post-infection mutation selection under positive evolutionary pressure (host-driven viral evolution). These mutations may reduce the effectiveness of the specific neutralizing immune response against the virus. We provide here evidence that apart from the selection of SARS-CoV-2 variants by the immune system, selection by the cellular receptor can just as well select variants which escape neutralization.
format Online
Article
Text
id pubmed-10598458
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-105984582023-10-26 Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response Devaux, Christian A. Fantini, Jacques Front Immunol Immunology Since the start of the SARS-CoV-2 pandemic, the rapid replacement of one lineage by another has been observed. Indeed, SARS-CoV-2 is evolving through a quasispecies mechanism leading to post-infection mutation selection under positive evolutionary pressure (host-driven viral evolution). These mutations may reduce the effectiveness of the specific neutralizing immune response against the virus. We provide here evidence that apart from the selection of SARS-CoV-2 variants by the immune system, selection by the cellular receptor can just as well select variants which escape neutralization. Frontiers Media S.A. 2023-10-10 /pmc/articles/PMC10598458/ /pubmed/37885880 http://dx.doi.org/10.3389/fimmu.2023.1252367 Text en Copyright © 2023 Devaux and Fantini https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Devaux, Christian A.
Fantini, Jacques
Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response
title Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response
title_full Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response
title_fullStr Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response
title_full_unstemmed Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response
title_short Possible contribution of rare alleles of human ACE2 in the emergence of SARS-CoV-2 variants escaping the immune response
title_sort possible contribution of rare alleles of human ace2 in the emergence of sars-cov-2 variants escaping the immune response
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598458/
https://www.ncbi.nlm.nih.gov/pubmed/37885880
http://dx.doi.org/10.3389/fimmu.2023.1252367
work_keys_str_mv AT devauxchristiana possiblecontributionofrareallelesofhumanace2intheemergenceofsarscov2variantsescapingtheimmuneresponse
AT fantinijacques possiblecontributionofrareallelesofhumanace2intheemergenceofsarscov2variantsescapingtheimmuneresponse

Ejemplares similares