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A hybrid energy-based and AI-based screening approach for the discovery of novel inhibitors of JAK3
The JAKs protein family is composed of four isoforms, and JAK3 has been regarded as a druggable target for the development of drugs to treat various diseases, including hematologic tumors, cancer, and neuronal death. Therefore, the discovery of JAK3 inhibitors with novel scaffolds possesses the pote...
Autores principales: | Wei, Juying, Pan, Youlu, Shen, Zheyuan, Shen, Liteng, Xu, Lei, Yu, Wenjuan, Huang, Wenhai |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598672/ https://www.ncbi.nlm.nih.gov/pubmed/37886358 http://dx.doi.org/10.3389/fmed.2023.1182227 |
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