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Characteristics of an advanced epilepsy treatment gap in a region in Japan

To investigate the quality of epilepsy care in a region in Japan that lacked specialised care, we retrospectively evaluated patients who visited our newly established epilepsy division between April 2018 and March 2021, and had been treated with anti-seizure medications (ASMs) for at least 1 year pr...

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Autores principales: Fukuyama, Tetsuhiro, Yabe, Manami, Nishioka, Makoto, Natsume, Takenori, Hoshino, Yuumi, Kanaya, Kohei, Takano, Kyoko, Kobayashi, Norimoto, Inoue, Yushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598686/
https://www.ncbi.nlm.nih.gov/pubmed/37886219
http://dx.doi.org/10.1016/j.ebr.2023.100628
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author Fukuyama, Tetsuhiro
Yabe, Manami
Nishioka, Makoto
Natsume, Takenori
Hoshino, Yuumi
Kanaya, Kohei
Takano, Kyoko
Kobayashi, Norimoto
Inoue, Yushi
author_facet Fukuyama, Tetsuhiro
Yabe, Manami
Nishioka, Makoto
Natsume, Takenori
Hoshino, Yuumi
Kanaya, Kohei
Takano, Kyoko
Kobayashi, Norimoto
Inoue, Yushi
author_sort Fukuyama, Tetsuhiro
collection PubMed
description To investigate the quality of epilepsy care in a region in Japan that lacked specialised care, we retrospectively evaluated patients who visited our newly established epilepsy division between April 2018 and March 2021, and had been treated with anti-seizure medications (ASMs) for at least 1 year prior. Of the 231 patients included, 169 had ongoing seizure episodes at first visit (seizure-persist group) and 62 had no seizure episodes for more than a year (seizure-free group). Eighty-three patients in the seizure-persist group had not received specialised epilepsy care, 15 had been treated with unnecessary medications, and seven had experienced side effects from ASMs. Twelve patients in the seizure-free group had been treated with unnecessary ASMs, 10 had been treated with ASMs with teratogenic potential and four had experienced ASM side effects. These patients could be classified as having an advanced epilepsy treatment gap (ETG) because they had not previously received necessary specialised care. The progressive decline in the number of patients with advanced ETG suggests that our new epilepsy division has addressed this issue. This study highlights that a significant number of patients with advanced ETGs exist in Japan and that proper countermeasures are required to address this gap.
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spelling pubmed-105986862023-10-26 Characteristics of an advanced epilepsy treatment gap in a region in Japan Fukuyama, Tetsuhiro Yabe, Manami Nishioka, Makoto Natsume, Takenori Hoshino, Yuumi Kanaya, Kohei Takano, Kyoko Kobayashi, Norimoto Inoue, Yushi Epilepsy Behav Rep Article To investigate the quality of epilepsy care in a region in Japan that lacked specialised care, we retrospectively evaluated patients who visited our newly established epilepsy division between April 2018 and March 2021, and had been treated with anti-seizure medications (ASMs) for at least 1 year prior. Of the 231 patients included, 169 had ongoing seizure episodes at first visit (seizure-persist group) and 62 had no seizure episodes for more than a year (seizure-free group). Eighty-three patients in the seizure-persist group had not received specialised epilepsy care, 15 had been treated with unnecessary medications, and seven had experienced side effects from ASMs. Twelve patients in the seizure-free group had been treated with unnecessary ASMs, 10 had been treated with ASMs with teratogenic potential and four had experienced ASM side effects. These patients could be classified as having an advanced epilepsy treatment gap (ETG) because they had not previously received necessary specialised care. The progressive decline in the number of patients with advanced ETG suggests that our new epilepsy division has addressed this issue. This study highlights that a significant number of patients with advanced ETGs exist in Japan and that proper countermeasures are required to address this gap. Elsevier 2023-10-16 /pmc/articles/PMC10598686/ /pubmed/37886219 http://dx.doi.org/10.1016/j.ebr.2023.100628 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Fukuyama, Tetsuhiro
Yabe, Manami
Nishioka, Makoto
Natsume, Takenori
Hoshino, Yuumi
Kanaya, Kohei
Takano, Kyoko
Kobayashi, Norimoto
Inoue, Yushi
Characteristics of an advanced epilepsy treatment gap in a region in Japan
title Characteristics of an advanced epilepsy treatment gap in a region in Japan
title_full Characteristics of an advanced epilepsy treatment gap in a region in Japan
title_fullStr Characteristics of an advanced epilepsy treatment gap in a region in Japan
title_full_unstemmed Characteristics of an advanced epilepsy treatment gap in a region in Japan
title_short Characteristics of an advanced epilepsy treatment gap in a region in Japan
title_sort characteristics of an advanced epilepsy treatment gap in a region in japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598686/
https://www.ncbi.nlm.nih.gov/pubmed/37886219
http://dx.doi.org/10.1016/j.ebr.2023.100628
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