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Elongation rate of RNA polymerase II affects pausing patterns across 3′ UTRs

Yeast mRNAs are polyadenylated at multiple sites in their 3′ untranslated regions (3′ UTRs), and poly(A) site usage is regulated by the rate of transcriptional elongation by RNA polymerase II (Pol II). Slow Pol II derivatives favor upstream poly(A) sites, and fast Pol II derivatives favor downstream...

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Detalles Bibliográficos
Autores principales:	Khitun, Alexandra, Brion, Christian, Moqtaderi, Zarmik, Geisberg, Joseph V., Churchman, L. Stirling, Struhl, Kevin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10598743/ https://www.ncbi.nlm.nih.gov/pubmed/37748648 http://dx.doi.org/10.1016/j.jbc.2023.105289

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