Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue

BACKGROUND: Quantification of drug-target binding is critical for confirming that drugs reach their intended protein targets, understanding the mechanism of action, and interpreting dose-response relationships. For covalent inhibitors, target engagement can be inferred by free target levels before a...

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Detalles Bibliográficos
Autores principales: Chambers, Andrew G., Chain, David C., Sweet, Steve M., Song, Zifeng, Martin, Philip L., Ellis, Matthew J., Rooney, Claire, Kim, Yeoun Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599008/
https://www.ncbi.nlm.nih.gov/pubmed/37880622
http://dx.doi.org/10.1186/s12014-023-09435-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599008/
https://www.ncbi.nlm.nih.gov/pubmed/37880622
http://dx.doi.org/10.1186/s12014-023-09435-8

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