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Mass spectrometry quantifies target engagement for a KRASG12C inhibitor in FFPE tumor tissue

BACKGROUND: Quantification of drug-target binding is critical for confirming that drugs reach their intended protein targets, understanding the mechanism of action, and interpreting dose-response relationships. For covalent inhibitors, target engagement can be inferred by free target levels before a...

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Detalles Bibliográficos
Autores principales:	Chambers, Andrew G., Chain, David C., Sweet, Steve M., Song, Zifeng, Martin, Philip L., Ellis, Matthew J., Rooney, Claire, Kim, Yeoun Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599008/ https://www.ncbi.nlm.nih.gov/pubmed/37880622 http://dx.doi.org/10.1186/s12014-023-09435-8

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