Blocking Mitochondrial Pyruvate Transport Alters Corneal Myofibroblast Phenotype: A New Target for Treating Fibrosis

PURPOSE: The purpose of this study was to critically test the hypothesis that mitochondrial pyruvate carrier (MPC) function is essential for maintenance of the corneal myofibroblast phenotype in vitro and in vivo. METHODS: Protein and mRNA for canonical profibrotic markers were assessed in cultured...

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Detalles Bibliográficos
Autores principales: Jeon, Kye-Im, Kumar, Ankita, Callan, Christine L., DeMagistris, Margaret, MacRae, Scott, Nehrke, Keith, Huxlin, Krystel R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2023
Materias:
Cornea
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599161/
https://www.ncbi.nlm.nih.gov/pubmed/37870848
http://dx.doi.org/10.1167/iovs.64.13.36

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599161/
https://www.ncbi.nlm.nih.gov/pubmed/37870848
http://dx.doi.org/10.1167/iovs.64.13.36

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