Cargando…
Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis
OBJECTIVE: Recurrent pregnancy loss (RPL) and pre‐eclampsia (PE) are immune‐related pregnancy complications that have been linked to CD4(+) T cells and their cytokines, which can be influenced by genetic polymorphisms. This meta‐analysis aimed to investigate the relationship between interleukin (IL)...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599280/ https://www.ncbi.nlm.nih.gov/pubmed/37904702 http://dx.doi.org/10.1002/iid3.1057 |
_version_ | 1785125736954200064 |
---|---|
author | Ma, Yue Ma, Mingyue Ye, Shenglong Liu, Yuanying Zhao, Xueqing Wang, Yongqing |
author_facet | Ma, Yue Ma, Mingyue Ye, Shenglong Liu, Yuanying Zhao, Xueqing Wang, Yongqing |
author_sort | Ma, Yue |
collection | PubMed |
description | OBJECTIVE: Recurrent pregnancy loss (RPL) and pre‐eclampsia (PE) are immune‐related pregnancy complications that have been linked to CD4(+) T cells and their cytokines, which can be influenced by genetic polymorphisms. This meta‐analysis aimed to investigate the relationship between interleukin (IL)‐17 and ‐27 polymorphisms and the susceptibility to RPL and PE. METHODS: All eligible case‐control studies published up to February 2023 were identified by searching PubMed, EMBASE, Cochrane, Web of Science, and Google Scholar. The risk of recurrent pregnancy loss and PE associated with the IL‐17 rs2275913, IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were estimated for each study. RESULTS: The meta‐analysis incorporated a total of 13 studies. The overall analysis indicated that IL‐17 rs2275913, IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were not significantly associated with immune‐related pregnancy complications, including RPL and PE. However, when the analysis was stratified by disease type, the IL‐17 rs2275913 polymorphism was found to be associated with an increased risk of RPL (recessive model AA/GA + GG: OR = 1.68, 95% confidence interval [CI]: 1.13–2.49, p = .01). CONCLUSIONS: The IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were not significantly associated with RPL and PE, whereas the IL‐17 rs2275913 polymorphism was associated with the susceptibility to recurrent miscarriage. |
format | Online Article Text |
id | pubmed-10599280 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105992802023-10-26 Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis Ma, Yue Ma, Mingyue Ye, Shenglong Liu, Yuanying Zhao, Xueqing Wang, Yongqing Immun Inflamm Dis Original Articles OBJECTIVE: Recurrent pregnancy loss (RPL) and pre‐eclampsia (PE) are immune‐related pregnancy complications that have been linked to CD4(+) T cells and their cytokines, which can be influenced by genetic polymorphisms. This meta‐analysis aimed to investigate the relationship between interleukin (IL)‐17 and ‐27 polymorphisms and the susceptibility to RPL and PE. METHODS: All eligible case‐control studies published up to February 2023 were identified by searching PubMed, EMBASE, Cochrane, Web of Science, and Google Scholar. The risk of recurrent pregnancy loss and PE associated with the IL‐17 rs2275913, IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were estimated for each study. RESULTS: The meta‐analysis incorporated a total of 13 studies. The overall analysis indicated that IL‐17 rs2275913, IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were not significantly associated with immune‐related pregnancy complications, including RPL and PE. However, when the analysis was stratified by disease type, the IL‐17 rs2275913 polymorphism was found to be associated with an increased risk of RPL (recessive model AA/GA + GG: OR = 1.68, 95% confidence interval [CI]: 1.13–2.49, p = .01). CONCLUSIONS: The IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were not significantly associated with RPL and PE, whereas the IL‐17 rs2275913 polymorphism was associated with the susceptibility to recurrent miscarriage. John Wiley and Sons Inc. 2023-10-25 /pmc/articles/PMC10599280/ /pubmed/37904702 http://dx.doi.org/10.1002/iid3.1057 Text en © 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Ma, Yue Ma, Mingyue Ye, Shenglong Liu, Yuanying Zhao, Xueqing Wang, Yongqing Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis |
title | Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis |
title_full | Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis |
title_fullStr | Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis |
title_full_unstemmed | Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis |
title_short | Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis |
title_sort | association of il‐17 and il‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: a systematic review and meta‐analysis |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599280/ https://www.ncbi.nlm.nih.gov/pubmed/37904702 http://dx.doi.org/10.1002/iid3.1057 |
work_keys_str_mv | AT mayue associationofil17andil27polymorphismswithsusceptibilitytorecurrentpregnancylossandpreeclampsiaasystematicreviewandmetaanalysis AT mamingyue associationofil17andil27polymorphismswithsusceptibilitytorecurrentpregnancylossandpreeclampsiaasystematicreviewandmetaanalysis AT yeshenglong associationofil17andil27polymorphismswithsusceptibilitytorecurrentpregnancylossandpreeclampsiaasystematicreviewandmetaanalysis AT liuyuanying associationofil17andil27polymorphismswithsusceptibilitytorecurrentpregnancylossandpreeclampsiaasystematicreviewandmetaanalysis AT zhaoxueqing associationofil17andil27polymorphismswithsusceptibilitytorecurrentpregnancylossandpreeclampsiaasystematicreviewandmetaanalysis AT wangyongqing associationofil17andil27polymorphismswithsusceptibilitytorecurrentpregnancylossandpreeclampsiaasystematicreviewandmetaanalysis |