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Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis

OBJECTIVE: Recurrent pregnancy loss (RPL) and pre‐eclampsia (PE) are immune‐related pregnancy complications that have been linked to CD4(+) T cells and their cytokines, which can be influenced by genetic polymorphisms. This meta‐analysis aimed to investigate the relationship between interleukin (IL)...

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Autores principales: Ma, Yue, Ma, Mingyue, Ye, Shenglong, Liu, Yuanying, Zhao, Xueqing, Wang, Yongqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599280/
https://www.ncbi.nlm.nih.gov/pubmed/37904702
http://dx.doi.org/10.1002/iid3.1057
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author Ma, Yue
Ma, Mingyue
Ye, Shenglong
Liu, Yuanying
Zhao, Xueqing
Wang, Yongqing
author_facet Ma, Yue
Ma, Mingyue
Ye, Shenglong
Liu, Yuanying
Zhao, Xueqing
Wang, Yongqing
author_sort Ma, Yue
collection PubMed
description OBJECTIVE: Recurrent pregnancy loss (RPL) and pre‐eclampsia (PE) are immune‐related pregnancy complications that have been linked to CD4(+) T cells and their cytokines, which can be influenced by genetic polymorphisms. This meta‐analysis aimed to investigate the relationship between interleukin (IL)‐17 and ‐27 polymorphisms and the susceptibility to RPL and PE. METHODS: All eligible case‐control studies published up to February 2023 were identified by searching PubMed, EMBASE, Cochrane, Web of Science, and Google Scholar. The risk of recurrent pregnancy loss and PE associated with the IL‐17 rs2275913, IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were estimated for each study. RESULTS: The meta‐analysis incorporated a total of 13 studies. The overall analysis indicated that IL‐17 rs2275913, IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were not significantly associated with immune‐related pregnancy complications, including RPL and PE. However, when the analysis was stratified by disease type, the IL‐17 rs2275913 polymorphism was found to be associated with an increased risk of RPL (recessive model AA/GA + GG: OR = 1.68, 95% confidence interval [CI]: 1.13–2.49, p = .01). CONCLUSIONS: The IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were not significantly associated with RPL and PE, whereas the IL‐17 rs2275913 polymorphism was associated with the susceptibility to recurrent miscarriage.
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spelling pubmed-105992802023-10-26 Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis Ma, Yue Ma, Mingyue Ye, Shenglong Liu, Yuanying Zhao, Xueqing Wang, Yongqing Immun Inflamm Dis Original Articles OBJECTIVE: Recurrent pregnancy loss (RPL) and pre‐eclampsia (PE) are immune‐related pregnancy complications that have been linked to CD4(+) T cells and their cytokines, which can be influenced by genetic polymorphisms. This meta‐analysis aimed to investigate the relationship between interleukin (IL)‐17 and ‐27 polymorphisms and the susceptibility to RPL and PE. METHODS: All eligible case‐control studies published up to February 2023 were identified by searching PubMed, EMBASE, Cochrane, Web of Science, and Google Scholar. The risk of recurrent pregnancy loss and PE associated with the IL‐17 rs2275913, IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were estimated for each study. RESULTS: The meta‐analysis incorporated a total of 13 studies. The overall analysis indicated that IL‐17 rs2275913, IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were not significantly associated with immune‐related pregnancy complications, including RPL and PE. However, when the analysis was stratified by disease type, the IL‐17 rs2275913 polymorphism was found to be associated with an increased risk of RPL (recessive model AA/GA + GG: OR = 1.68, 95% confidence interval [CI]: 1.13–2.49, p = .01). CONCLUSIONS: The IL‐17 rs763780, IL‐27 rs153109, and IL‐27 rs17855750 polymorphisms were not significantly associated with RPL and PE, whereas the IL‐17 rs2275913 polymorphism was associated with the susceptibility to recurrent miscarriage. John Wiley and Sons Inc. 2023-10-25 /pmc/articles/PMC10599280/ /pubmed/37904702 http://dx.doi.org/10.1002/iid3.1057 Text en © 2023 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Ma, Yue
Ma, Mingyue
Ye, Shenglong
Liu, Yuanying
Zhao, Xueqing
Wang, Yongqing
Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis
title Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis
title_full Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis
title_fullStr Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis
title_full_unstemmed Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis
title_short Association of IL‐17 and IL‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: A systematic review and meta‐analysis
title_sort association of il‐17 and il‐27 polymorphisms with susceptibility to recurrent pregnancy loss and pre‐eclampsia: a systematic review and meta‐analysis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599280/
https://www.ncbi.nlm.nih.gov/pubmed/37904702
http://dx.doi.org/10.1002/iid3.1057
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