Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line

The most often diagnosed and fatal malignancy in women is breast cancer. The International Agency for Research on Cancer (IARC) estimates that there are 2.26 million new cases of cancer in 2020. Adoptive cell therapy using T cells with chimeric antigen receptor shows potential for the treatment of s...

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Autores principales: Valiullina, Aigul Kh., Zmievskaya, Ekaterina A., Ganeeva, Irina A., Zhuravleva, Margarita N., Garanina, Ekaterina E., Rizvanov, Albert A., Petukhov, Alexey V., Bulatov, Emil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599594/
https://www.ncbi.nlm.nih.gov/pubmed/37886737
http://dx.doi.org/10.22099/mbrc.2023.47125.1820
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author Valiullina, Aigul Kh.
Zmievskaya, Ekaterina A.
Ganeeva, Irina A.
Zhuravleva, Margarita N.
Garanina, Ekaterina E.
Rizvanov, Albert A.
Petukhov, Alexey V.
Bulatov, Emil R.
author_facet Valiullina, Aigul Kh.
Zmievskaya, Ekaterina A.
Ganeeva, Irina A.
Zhuravleva, Margarita N.
Garanina, Ekaterina E.
Rizvanov, Albert A.
Petukhov, Alexey V.
Bulatov, Emil R.
author_sort Valiullina, Aigul Kh.
collection PubMed
description The most often diagnosed and fatal malignancy in women is breast cancer. The International Agency for Research on Cancer (IARC) estimates that there are 2.26 million new cases of cancer in 2020. Adoptive cell therapy using T cells with chimeric antigen receptor shows potential for the treatment of solid tumors, such as breast cancer. In this work the effectiveness of CAR-T cells against monolayer and three-dimensional bioprinted tumor-like structures made of modified MCF-7 breast cancer cells was assessed. The cytokine profile of supernatants after co-cultivation of MCF-7 tumor cell models with CAR-T cells was also measured to reveal the inflammatory background associated with this interaction.
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spelling pubmed-105995942023-10-26 Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line Valiullina, Aigul Kh. Zmievskaya, Ekaterina A. Ganeeva, Irina A. Zhuravleva, Margarita N. Garanina, Ekaterina E. Rizvanov, Albert A. Petukhov, Alexey V. Bulatov, Emil R. Mol Biol Res Commun Original Article The most often diagnosed and fatal malignancy in women is breast cancer. The International Agency for Research on Cancer (IARC) estimates that there are 2.26 million new cases of cancer in 2020. Adoptive cell therapy using T cells with chimeric antigen receptor shows potential for the treatment of solid tumors, such as breast cancer. In this work the effectiveness of CAR-T cells against monolayer and three-dimensional bioprinted tumor-like structures made of modified MCF-7 breast cancer cells was assessed. The cytokine profile of supernatants after co-cultivation of MCF-7 tumor cell models with CAR-T cells was also measured to reveal the inflammatory background associated with this interaction. Shiraz University 2023 /pmc/articles/PMC10599594/ /pubmed/37886737 http://dx.doi.org/10.22099/mbrc.2023.47125.1820 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Valiullina, Aigul Kh.
Zmievskaya, Ekaterina A.
Ganeeva, Irina A.
Zhuravleva, Margarita N.
Garanina, Ekaterina E.
Rizvanov, Albert A.
Petukhov, Alexey V.
Bulatov, Emil R.
Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
title Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
title_full Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
title_fullStr Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
title_full_unstemmed Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
title_short Сytotoxic effect of CAR-T cells against modified MCF-7 breast cancer cell line
title_sort сytotoxic effect of car-t cells against modified mcf-7 breast cancer cell line
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599594/
https://www.ncbi.nlm.nih.gov/pubmed/37886737
http://dx.doi.org/10.22099/mbrc.2023.47125.1820
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