Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer

Recent studies have pointed to PARP1 trapping as a key determinant of the anticancer effects of PARP1 inhibitors (PARPi). We identified RNF114, as a PARylation-dependent, E3 ubiquitin ligase involved in DNA damage response. Upon sensing genotoxicity, RNF114 was recruited, in a PAR-dependent manner,...

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Detalles Bibliográficos
Autores principales: Li, Peng, Zhen, Yuanli, Kim, Chiho, Liu, Zhengshuai, Hao, Jianwei, Deng, Heping, Deng, Hejun, Zhou, Min, Wang, Xu-Dong, Qin, Tian, Yu, Yonghao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599614/
https://www.ncbi.nlm.nih.gov/pubmed/37878693
http://dx.doi.org/10.1126/sciadv.adg7752

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599614/
https://www.ncbi.nlm.nih.gov/pubmed/37878693
http://dx.doi.org/10.1126/sciadv.adg7752

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