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“Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction
Abnormal brain–gut interaction is considered the core pathological mechanism behind the disorders of gut–brain interaction (DGBI), in which the intestinal microbiota plays an important role. Microglia are the “sentinels” of the central nervous system (CNS), which participate in tissue damage caused...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599645/ https://www.ncbi.nlm.nih.gov/pubmed/37074139 http://dx.doi.org/10.1093/procel/pwad020 |
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author | Zheng, Haonan Zhang, Cunzheng Zhang, Jindong Duan, Liping |
author_facet | Zheng, Haonan Zhang, Cunzheng Zhang, Jindong Duan, Liping |
author_sort | Zheng, Haonan |
collection | PubMed |
description | Abnormal brain–gut interaction is considered the core pathological mechanism behind the disorders of gut–brain interaction (DGBI), in which the intestinal microbiota plays an important role. Microglia are the “sentinels” of the central nervous system (CNS), which participate in tissue damage caused by traumatic brain injury, resist central infection and participate in neurogenesis, and are involved in the occurrence of various neurological diseases. With in-depth research on DGBI, we could find an interaction between the intestinal microbiota and microglia and that they are jointly involved in the occurrence of DGBI, especially in individuals with comorbidities of mental disorders, such as irritable bowel syndrome (IBS). This bidirectional regulation of microbiota and microglia provides a new direction for the treatment of DGBI. In this review, we focus on the role and underlying mechanism of the interaction between gut microbiota and microglia in DGBI, especially IBS, and the corresponding clinical application prospects and highlight its potential to treat DGBI in individuals with psychiatric comorbidities. |
format | Online Article Text |
id | pubmed-10599645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-105996452023-10-26 “Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction Zheng, Haonan Zhang, Cunzheng Zhang, Jindong Duan, Liping Protein Cell Reviews Abnormal brain–gut interaction is considered the core pathological mechanism behind the disorders of gut–brain interaction (DGBI), in which the intestinal microbiota plays an important role. Microglia are the “sentinels” of the central nervous system (CNS), which participate in tissue damage caused by traumatic brain injury, resist central infection and participate in neurogenesis, and are involved in the occurrence of various neurological diseases. With in-depth research on DGBI, we could find an interaction between the intestinal microbiota and microglia and that they are jointly involved in the occurrence of DGBI, especially in individuals with comorbidities of mental disorders, such as irritable bowel syndrome (IBS). This bidirectional regulation of microbiota and microglia provides a new direction for the treatment of DGBI. In this review, we focus on the role and underlying mechanism of the interaction between gut microbiota and microglia in DGBI, especially IBS, and the corresponding clinical application prospects and highlight its potential to treat DGBI in individuals with psychiatric comorbidities. Oxford University Press 2023-04-19 /pmc/articles/PMC10599645/ /pubmed/37074139 http://dx.doi.org/10.1093/procel/pwad020 Text en ©The Author(s) 2023. Published by Oxford University Press on behalf of Higher Education Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Zheng, Haonan Zhang, Cunzheng Zhang, Jindong Duan, Liping “Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction |
title | “Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction |
title_full | “Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction |
title_fullStr | “Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction |
title_full_unstemmed | “Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction |
title_short | “Sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction |
title_sort | “sentinel or accomplice”: gut microbiota and microglia crosstalk in disorders of gut–brain interaction |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599645/ https://www.ncbi.nlm.nih.gov/pubmed/37074139 http://dx.doi.org/10.1093/procel/pwad020 |
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