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Molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma

Cancer-intrinsic immune evasion (IE) to cells is a critical factor in tumour growth and progression, yet the molecular characterization of IE genes (IEGs) in osteosarcoma remains underexplored. In this study, 85 osteosarcoma patients were comprehensively analyzed based on 182 IEGs, leading to the id...

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Autores principales: Zhao, Xiaokun, Zhang, Jian, Liu, Jiahao, Luo, Shengzhong, Ding, Rui, Miao, Xinxin, Wu, Tianlong, Jia, Jingyu, Cheng, Xigao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599718/
https://www.ncbi.nlm.nih.gov/pubmed/37796192
http://dx.doi.org/10.18632/aging.205074
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author Zhao, Xiaokun
Zhang, Jian
Liu, Jiahao
Luo, Shengzhong
Ding, Rui
Miao, Xinxin
Wu, Tianlong
Jia, Jingyu
Cheng, Xigao
author_facet Zhao, Xiaokun
Zhang, Jian
Liu, Jiahao
Luo, Shengzhong
Ding, Rui
Miao, Xinxin
Wu, Tianlong
Jia, Jingyu
Cheng, Xigao
author_sort Zhao, Xiaokun
collection PubMed
description Cancer-intrinsic immune evasion (IE) to cells is a critical factor in tumour growth and progression, yet the molecular characterization of IE genes (IEGs) in osteosarcoma remains underexplored. In this study, 85 osteosarcoma patients were comprehensively analyzed based on 182 IEGs, leading to the identification of two IE clusters linked to distinct biological processes and clinical outcomes. In addition, two IE clusters demonstrated diverse immune cell infiltration patterns, with IEGcluster A displaying increased levels compared to IEGcluster B. Moreover, an IE score was identified as an independent prognostic factor and nomogram may serve as a practical tool for the individual prognostic evaluation of patients with osteosarcoma. Finally, GBP1, a potential biomarker with high expression in osteosarcoma was identified. The findings of this study highlight the presence of two IE clusters, each associated with differing patient outcomes and immune infiltration properties. The IE score may serve to assess individual patient IE characteristics, enhance comprehension of immune features, and guide more efficacious treatment approaches.
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spelling pubmed-105997182023-10-26 Molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma Zhao, Xiaokun Zhang, Jian Liu, Jiahao Luo, Shengzhong Ding, Rui Miao, Xinxin Wu, Tianlong Jia, Jingyu Cheng, Xigao Aging (Albany NY) Research Paper Cancer-intrinsic immune evasion (IE) to cells is a critical factor in tumour growth and progression, yet the molecular characterization of IE genes (IEGs) in osteosarcoma remains underexplored. In this study, 85 osteosarcoma patients were comprehensively analyzed based on 182 IEGs, leading to the identification of two IE clusters linked to distinct biological processes and clinical outcomes. In addition, two IE clusters demonstrated diverse immune cell infiltration patterns, with IEGcluster A displaying increased levels compared to IEGcluster B. Moreover, an IE score was identified as an independent prognostic factor and nomogram may serve as a practical tool for the individual prognostic evaluation of patients with osteosarcoma. Finally, GBP1, a potential biomarker with high expression in osteosarcoma was identified. The findings of this study highlight the presence of two IE clusters, each associated with differing patient outcomes and immune infiltration properties. The IE score may serve to assess individual patient IE characteristics, enhance comprehension of immune features, and guide more efficacious treatment approaches. Impact Journals 2023-10-04 /pmc/articles/PMC10599718/ /pubmed/37796192 http://dx.doi.org/10.18632/aging.205074 Text en Copyright: © 2023 Zhao et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhao, Xiaokun
Zhang, Jian
Liu, Jiahao
Luo, Shengzhong
Ding, Rui
Miao, Xinxin
Wu, Tianlong
Jia, Jingyu
Cheng, Xigao
Molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma
title Molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma
title_full Molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma
title_fullStr Molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma
title_full_unstemmed Molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma
title_short Molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma
title_sort molecular characterization of cancer-intrinsic immune evasion genes indicates prognosis and tumour microenvironment infiltration in osteosarcoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599718/
https://www.ncbi.nlm.nih.gov/pubmed/37796192
http://dx.doi.org/10.18632/aging.205074
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