Paroxetine protects against bleomycin-induced pulmonary fibrosis by blocking GRK2/Smad3 pathway

G protein-coupled receptor kinase-2 (GRK2) is involved in TGF-β1-induced activation of lung fibroblasts, which could give rise to the pathogenesis of pulmonary fibrosis. Paroxetine (PRXT) serves as a selective GRK2 inhibitor which is widely used to treat anxiety and depression for several decades. H...

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Detalles Bibliográficos
Autores principales: Zhao, Kaochang, Nie, Hanxiang, Tang, Zheng, Chen, Guozhong, Huang, Jizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599755/
https://www.ncbi.nlm.nih.gov/pubmed/37815883
http://dx.doi.org/10.18632/aging.205092

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10599755/
https://www.ncbi.nlm.nih.gov/pubmed/37815883
http://dx.doi.org/10.18632/aging.205092

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